ArticleAmerican journal of physiology. Cell physiology2015
Aquaporins-2 and -4 regulate glycogen metabolism and survival during hyposmotic-anoxic stress in Caenorhabditis elegans.
Article in American journal of physiology. Cell physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Article
- Glucose as a Major Antioxidant: When, What for and Why It Fails?Antioxidants (Basel, Switzerland) · 2020Review
- A new method for measuring the size of nematodes using image processing.Biology methods & protocols · 2020Article
- Stress Regulates Aquaporin-8 Permeability to Impact Cell Growth and Survival.Antioxidants & redox signaling · 2016Article
- Adaptation to Temporally Fluctuating Environments by the Evolution of Maternal Effects.PLoS biology · 2016Article
- FLCN and AMPK Confer Resistance to Hyperosmotic Stress via Remodeling of Glycogen Stores.PLoS genetics · 2015Article
- Article
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Authors and funding
2 authors.
Funding
Abstract
Periods of oxygen deprivation can lead to ion and water imbalances in affected tissues that manifest as swelling (edema). Although oxygen deprivation-induced edema is a major contributor to injury in clinical ischemic diseases such as heart attack and stroke, the pathophysiology of this process is incompletely understood. In the present study we investigate the impact of aquaporin-mediated water transport on survival in a Caenorhabditis elegans model of edema formation during complete oxygen deprivation (anoxia). We find that nematodes lacking aquaporin water channels in tissues that interface with the surrounding environment display decreased edema formation and improved survival rates in anoxia. We also find that these animals have significantly reduced demand for glycogen as an energetic substrate during anoxia. Together, our data suggest that reductions in membrane water permeability may be sufficient to induce a hypometabolic state during oxygen deprivation that reduces injury and extends survival limits.
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