ArticleCell cycle (Georgetown, Tex.)2015
A novel role for the condensin II complex in cellular senescence.
Article in Cell cycle (Georgetown, Tex.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- NCAPD3 is a prognostic biomarker and is correlated with immune infiltrates in glioma.Histology and histopathology · 2024Article
- Regulation of the mitotic chromosome folding machines.The Biochemical journal · 2022Article
- A mini-review of the role of condensin in human nervous system diseases.Frontiers in molecular neuroscience · 2022Review
- Article
- Explore a novel function of human condensins in cellular senescence.Cell & bioscience · 2020Review
- A multidimensional systems biology analysis of cellular senescence in aging and disease.Genome biology · 2020Article
- Involvement of condensin in cellular senescence through gene regulation and compartmental reorganization.Nature communications · 2019Article
- KDM3A and KDM4C Regulate Mesenchymal Stromal Cell Senescence and Bone Aging via Condensin-mediated Heterochromatin Reorganization.iScience · 2019Article
- ARID1A spatially partitions interphase chromosomes.Science advances · 2019Article
- Comparing and Contrasting the Effects ofGenetics · 2018Article
- Architectural alterations of the fission yeast genome during the cell cycle.Nature structural & molecular biology · 2017Article
- DNA methylation map in circulating leukocytes mirrors subcutaneous adipose tissue methylation pattern: a genome-wide analysis from non-obese and obese patients.Scientific reports · 2017Article
- Genome-wide association analysis of chronic lymphocytic leukaemia, Hodgkin lymphoma and multiple myeloma identifies pleiotropic risk loci.Scientific reports · 2017Article
- Old cells, new tricks: chromatin structure in senescence.Mammalian genome : official journal of the International Mammalian Genome Society · 2016Review
- Involvement of condensin-directed gene associations in the organization and regulation of chromosome territories during the cell cycle.Nucleic acids research · 2016Article
- The expanding territories of condensin II.Cell cycle (Georgetown, Tex.) · 2015Article
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4 authors.
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Abstract
Although cellular senescence is accompanied by global alterations in genome architecture, how the genome is restructured during the senescent processes is not well understood. Here, we show that the hCAP-H2 subunit of the condensin II complex exists as either a full-length protein or an N-terminus truncated variant (ΔN). While the full-length hCAP-H2 associates with mitotic chromosomes, the ΔN variant exists as an insoluble nuclear structure. When overexpressed, both hCAP-H2 isoforms assemble this nuclear architecture and induce senescence-associated heterochromatic foci (SAHF). The hCAP-H2ΔN protein accumulates as cells approach senescence, and hCAP-H2 knockdown inhibits oncogene-induced senescence. This study identifies a novel mechanism whereby condensin drives senescence via nuclear/genomic reorganization.
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