ArticleBMC genomics2015
Unravelling the genome of Holy basil: an "incomparable" "elixir of life" of traditional Indian medicine.
Article in BMC genomics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 72 citations in OpenAlex.
- Highly efficient production ofSynthetic and systems biotechnology · 2027Article
- Genome-Wide Identification and Expression Analysis of the Dof Transcription Factor Family inInternational journal of molecular sciences · 2026Article
- Integration of CRISPR/Cas9 with multi-omics technologies to engineer secondary metabolite productions in medicinal plant: Challenges and Prospects.Functional & integrative genomics · 2024Review
- Development of an allele-specific PCR (AS-PCR) method for identifying high-methyl eugenol-containing purple Tulsi (Ocimum tenuiflorum L.) in market samples.Molecular biology reports · 2024Article
- Tag and Snag: A New Platform for Bioactive Natural Product Screening from Mixtures.Molecules (Basel, Switzerland) · 2023Article
- Challenges in Medicinal and Aromatic Plants DNA Barcoding-Lessons from the Lamiaceae.Plants (Basel, Switzerland) · 2022Review
- Virus-Induced Gene Silencing for Functional Genomics of Specialized Metabolism in Medicinal Plants.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Phytometabolite profiling of Coronil, a herbal medicine for COVID-19, its identification by mass-spectroscopy and quality validation on liquid chromatographic platforms.Journal of separation science · 2021Article
- Antifungal and Insecticidal Potential of the Essential Oil fromPlants (Basel, Switzerland) · 2021Article
- Review
- The genome sequence of tetraploid sweet basil, Ocimum basilicum L., provides tools for advanced genome editing and molecular breeding.DNA research : an international journal for rapid publication of reports on genes and genomes · 2020Article
- An extreme-phenotype genome-wide association study identifies candidate cannabinoid pathway genes in Cannabis.Scientific reports · 2020Article
- Anthocyanins from3 Biotech · 2020Article
- Comparative temporal metabolomics studies to investigate interspecies variation in three Ocimum species.Scientific reports · 2020Article
- A Combination of Linalool, Vitamin C, and Copper Synergistically Triggers Reactive Oxygen Species and DNA Damage and InhibitsApplied and environmental microbiology · 2019Article
- Molecular authentication ofSaudi journal of biological sciences · 2019Article
- Ocimum metabolomics in response to abiotic stresses: Cold, flood, drought and salinity.PloS one · 2019Article
- Draft genome of a high value tropical timber tree, Teak (Tectona grandis L. f): insights into SSR diversity, phylogeny and conservation.DNA research : an international journal for rapid publication of reports on genes and genomes · 2018Article
- Herbal genomics as tools for dissecting new metabolic pathways of unexplored medicinal plants and drug discovery.Biochimie open · 2018Review
- Population structure, genetic diversity and downy mildew resistance among Ocimum species germplasm.BMC plant biology · 2018Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOcimum sanctum L. (O. tenuiflorum) family-Lamiaceae is an important component of Indian tradition of medicine as well as culture around the world, and hence is known as "Holy basil" in India. This plant is mentioned in the ancient texts of Ayurveda as an "elixir of life" (life saving) herb and worshipped for over 3000 years due to its healing properties. Although used in various ailments, validation of molecules for differential activities is yet to be fully analyzed, as about 80 % of the patents on this plant are on extracts or the plant parts, and mainly focussed on essential oil components. With a view to understand the full metabolic potential of this plant whole nuclear and chloroplast genomes were sequenced for the first time combining the sequence data from 4 libraries and three NGS platforms.
resultsThe saturated draft assembly of the genome was about 386 Mb, along with the plastid genome of 142,245 bp, turning out to be the smallest in Lamiaceae. In addition to SSR markers, 136 proteins were identified as homologous to five important plant genomes. Pathway analysis indicated an abundance of phenylpropanoids in O. sanctum. Phylogenetic analysis for chloroplast proteome placed Salvia miltiorrhiza as the nearest neighbor. Comparison of the chemical compounds and genes availability in O. sanctum and S. miltiorrhiza indicated the potential for the discovery of new active molecules.
conclusionThe genome sequence and annotation of O. sanctum provides new insights into the function of genes and the medicinal nature of the metabolites synthesized in this plant. This information is highly beneficial for mining biosynthetic pathways for important metabolites in related species.
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