ArticlePloS one2015
Nerve cross-bridging to enhance nerve regeneration in a rat model of delayed nerve repair.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Role of donor nerves in supercharge end-to-side nerve transfer: A rat model study of varying injury severity.PloS one · 2026Article
- Anterior Interosseus to Ulnar Motor Nerve Transfers: A Canadian Perspective.Hand (New York, N.Y.) · 2024Article
- Brief Electrical Stimulation Promotes Recovery after Surgical Repair of Injured Peripheral Nerves.International journal of molecular sciences · 2024Review
- Nerve function restoration following targeted muscle reinnervation after varying delayed periods.Neural regeneration research · 2023Article
- Molecular Basis of Surgical Coaptation Techniques in Peripheral Nerve Injuries.Journal of clinical medicine · 2023Review
- Platelet-Rich Plasma Gel-Loaded Collagen/Chitosan Composite Film Accelerated Rat Sciatic Nerve Injury Repair.ACS omega · 2023Article
- Peroneal Nerve Repair with Cross-Bridge Ladder Technique: Parallel End-to-Side Neurorrhaphies.Journal of brachial plexus and peripheral nerve injury · 2023Article
- Reverse End-to-Side (Supercharging) Nerve Transfer: Conceptualization, Validation, and Translation.Hand (New York, N.Y.) · 2022Review
- Neurotization of the human cornea - A comprehensive review and an interim report.Indian journal of ophthalmology · 2022Review
- The impact of different exercise protocols on rat soleus muscle reinnervation and recovery following peripheral nerve lesion and regeneration.Frontiers in physiology · 2022Article
- Cross-Palm Nerve Grafts to Enhance Sensory Recovery in Severe Ulnar Neuropathy.Hand (New York, N.Y.) · 2020Article
- Therapeutic strategies for peripheral nerve injury: decellularized nerve conduits and Schwann cell transplantation.Neural regeneration research · 2019Review
- Nerve stepping stone has minimal impact in aiding regeneration across long acellular nerve allografts.Muscle & nerve · 2018Article
- Cross-Face Nerve Grafting with Infraorbital Nerve Pathway Protection: Anatomic and Histomorphometric Feasibility Study.Plastic and reconstructive surgery. Global open · 2016Article
- Electrical Stimulation to Enhance Axon Regeneration After Peripheral Nerve Injuries in Animal Models and Humans.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2016Review
- Delayed peripheral nerve repair: methods, including surgical 'cross-bridging' to promote nerve regeneration.Neural regeneration research · 2015Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
There are currently no available options to promote nerve regeneration through chronically denervated distal nerve stumps. Here we used a rat model of delayed nerve repair asking of prior insertion of side-to-side cross-bridges between a donor tibial (TIB) nerve and a recipient denervated common peroneal (CP) nerve stump ameliorates poor nerve regeneration. First, numbers of retrogradely-labelled TIB neurons that grew axons into the nerve stump within three months, increased with the size of the perineurial windows opened in the TIB and CP nerves. Equal numbers of donor TIB axons regenerated into CP stumps either side of the cross-bridges, not being affected by target neurotrophic effects, or by removing the perineurium to insert 5-9 cross-bridges. Second, CP nerve stumps were coapted three months after inserting 0-9 cross-bridges and the number of 1) CP neurons that regenerated their axons within three months or 2) CP motor nerves that reinnervated the extensor digitorum longus (EDL) muscle within five months was determined by counting and motor unit number estimation (MUNE), respectively. We found that three but not more cross-bridges promoted the regeneration of axons and reinnervation of EDL muscle by all the CP motoneurons as compared to only 33% regenerating their axons when no cross-bridges were inserted. The same 3-fold increase in sensory nerve regeneration was found. In conclusion, side-to-side cross-bridges ameliorate poor regeneration after delayed nerve repair possibly by sustaining the growth-permissive state of denervated nerve stumps. Such autografts may be used in human repair surgery to improve outcomes after unavoidable delays.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.