ArticleMolecules (Basel, Switzerland)2015
Comparative Studies on Polyphenolic Composition, Antioxidant and Diuretic Effects of Nigella sativa L. (Black Cumin) and Nigella damascena L. (Lady-in-a-Mist) Seeds.
Article in Molecules (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- Comparative analysis of phytochemical traits, proximate composition, and metabolite diversity in Nigella sativa L. genotypes from India.Scientific reports · 2026Article
- Fatty acids, polyphenols and volatiles as predictive biomarkers of cold-pressed oil stability.Food chemistry: X · 2026Article
- Exploring potential phytocompounds from black cumin as drug molecules against SARS-CoV-2 infections through bioinformatics analysis.PloS one · 2026Article
- Phytochemical Characterization ofPharmaceuticals (Basel, Switzerland) · 2025Article
- Advances in Kaempferol: Extraction, Biosynthesis, and Application with Antibacterial Agents.Antibiotics (Basel, Switzerland) · 2025Review
- The Effect of the Extraction Method on the Content of Bioactive Compounds and the Biological Activity ofMolecules (Basel, Switzerland) · 2025Article
- Impact of Pretreatment Methods on Yield and Composition of Cold-Pressed Black Cumin (Foods (Basel, Switzerland) · 2025Article
- Nigella sativa oil attenuates inflammation and oxidative stress in experimental myocardial infarction.BMC complementary medicine and therapies · 2024Article
- Nutrient utilization, growth performance, and antioxidative status of Barki lambs fed diets supplemented with black (Nigella sativa) and rocket (Eruca sativa) seeds.Tropical animal health and production · 2024Article
- Phytochemical Characterization, Antioxidant, and Anti-Proliferative Activities of Wild and CultivatedAntioxidants (Basel, Switzerland) · 2024Article
- The Use ofBiomedicines · 2024Review
- Assessment of the Diuretic Effect of the Leaves ofJournal of experimental pharmacology · 2024Article
- Evaluation of Diuretic Activity of Aqueous and Hydro Methanolic Crude Extracts and Solvent Fraction of the Hydromethanolic Flower Extract ofJournal of experimental pharmacology · 2024Article
- The mint versus Covid hypothesis.Medical hypotheses · 2023Article
- Fabrication of a Polycaprolactone/Chitosan Nanofibrous Scaffold Loaded withBiotech (Basel (Switzerland)) · 2023Article
- Biological Properties, Phenolic Profile, and Botanical Aspect ofMolecules (Basel, Switzerland) · 2023Article
- D-Ribose-Induced Glycation and Its Attenuation by the Aqueous Extract ofMedicina (Kaunas, Lithuania) · 2022Article
- Quality Parameters of PE-Pomace Based Membranes.Membranes · 2022Article
- Black Cumin (Microorganisms · 2022Article
- A preliminary study of the chemical composition and bioactivity ofFrontiers in nutrition · 2022Article
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
This study was performed to evaluate the phenolic profile, antioxidant and diuretic effects of black cumin and lady-in-a-mist seeds. In the phenolic profile, differences between the two species are significant. Qualitative and quantitative analyses of the phenolic compounds were performed using a HPLC-UV/MS method. Hyperoside was the only identified flavonoid glycoside (1.08 ± 0.01 μg∙g-1 dw plant material), in the N. damascena extract. Regarding the flavonol profile, kaempferol was identified before the hydrolysis, only in the N. sativa extract (6.06 ± 0.02 μg∙g-1 dw plant material) and quercetin only in N. damascena seeds (14.35 ± 0.02 μg∙g-1 dw plant material). The antioxidant potential of the two species was tested through several electron transfer assays, which indicated, excepting for the FRAP assay, N. damascena as exhibiting a higher free radical scavenging activity. The diuretic activity of the two extracts was tested using a rat-experimental model on acute diuresis. Administration of the ethanolic extract of N. sativa (100 mg∙kg-1) resulted in a significant increase in urine volume, although less than found with the reference drug; in addition N. damascena extract did not present a diuretic effect. In reference to the elimination of Na+, K+ and uric acid, the black cumin extract exhibited a higher natriuretic than kaluretic effect and a similar uricosuric effect with control and N. damascena. For N. damascena, the Na+/K+ ratio was sub unitary, but not due to an increasing of the kaluretic effect, but mostly to a decrease of Na+ excretion.
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