SynthesisInternational journal of molecular sciences2015
Are MTHFR C677T and MTRR A66G Polymorphisms Associated with Overweight/Obesity Risk? From a Case-Control to a Meta-Analysis of 30,327 Subjects.
Synthesis in International journal of molecular sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association Between MTHFR C677T Polymorphism and Susceptibility to Autism Spectrum Disorders: A Meta-Analysis in Chinese Han Population.Frontiers in pediatrics · 2021Pooled it
- Case report: Rare variants in theFrontiers in psychiatry · 2024Article
- The Implication of a Polymorphism in the Methylenetetrahydrofolate Reductase Gene in Homocysteine Metabolism and Related Civilisation Diseases.International journal of molecular sciences · 2023Review
- Association of MTHFR and TYMS gene polymorphisms with the susceptibility to HCC in Egyptian HCV cirrhotic patients.Clinical and experimental medicine · 2022Article
- Genetic factors associated with obesity risks in a Kazakhstani population.BMJ nutrition, prevention & health · 2021Article
- Association ofFrontiers in psychiatry · 2021Article
- C677T Polymorphism in theFrontiers in psychiatry · 2020Article
- Association of the MTHFR 677C>T Polymorphism with Obesity and Biochemical Variables in a Young Population of Mexico.Journal of medical biochemistry · 2019Article
- Role of Personalized Nutrition in Chronic-Degenerative Diseases.Nutrients · 2019Review
- Plausible relationship between homocysteine and obesity risk viaDiabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
- Neck circumference associated with arterial blood pressures and hypertension: A cross-sectional community-based study in northern Han Chinese.Scientific reports · 2017Article
- Additive Interaction of MTHFR C677T and MTRR A66G Polymorphisms with Being Overweight/Obesity on the Risk of Type 2 Diabetes.International journal of environmental research and public health · 2016Article
Corrections and comments
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Authors and funding
10 authors.
Funding
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Abstract
Several studies have examined the associations of methylenetetrahydrofolate reductase (MTHFR) C677T and methionine synthase reductase (MTRR) A66G polymorphisms with being overweight/obesity. However, the results are still controversial. We therefore conducted a case-control study (517 cases and 741 controls) in a Chinese Han population and then performed a meta-analysis by combining previous studies (5431 cases and 24,896 controls). In our case-control study, the MTHFR C677T polymorphism was not significantly associated with being overweight/obesity when examining homozygous codominant, heterozygous codominant, dominant, recessive and allelic genetic models. The following meta-analysis confirmed our case-control results. Heterogeneity was minimal in the overall analysis, and sensitivity analyses and publication bias tests indicated that the meta-analytic results were reliable. Similarly, both the case-control study and meta-analysis found no significant association between the MTRR A66G polymorphism and being overweight/obesity. However, sensitivity analyses showed that the associations between the MTRR A66G polymorphism and being overweight/obesity became significant in the dominant, heterozygous codominant and allelic models after excluding our case-control study. The results from our case-control study and meta-analysis suggest that both of the two polymorphisms are not associated with being overweight/obesity. Further large-scale population-based studies, especially for the MTRR A66G polymorphism, are still needed to confirm or refute our findings.
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