Evidence map›Paper›PMID 26016454›Full record

ArticleChinese journal of integrative medicine2019

Xijiao Dihuang Decoction () and Rehmannia glutinosa Libosch. protect mice against lipopolysaccharide and tumor necrosis factor alpha-induced acute liver failure.

Yan-Min Liu, Liu-Luan Zhu, Rui Li, Jin-Liang Zhang, Shan-Shan Yao, Xiao-Bing Zhou, Hui Zeng, Xian-Bo Wang

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Article in Chinese journal of integrative medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Systematic Review on Chinese Herbal Medicine Induced Liver Injury.Evidence-based complementary and alternative medicine : eCAM · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yan-Min LiuCenter of Integrative Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
Liu-Luan ZhuBeijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
Rui LiBeijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
Jin-Liang ZhangCenter of Integrative Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
Shan-Shan YaoCenter of Integrative Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
Xiao-Bing ZhouCenter of Integrative Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
Hui ZengBeijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China. zenghui@ccmu.edu.cn.
Xian-Bo WangCenter of Integrative Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China. wangxb@ccmu.edu.cn.
Beijing Ditan Hospital · CNCapital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the hepatoprotective effect of Xijiao Dihuang Decoction (, XJDHD) on lipopolysaccharide (LPS)- and tumor necrosis factor alpha (TNF-α)-induced acute liver failure (ALF) as well as the underlying mechanism of action, and to clarify the key herbs and components of XJDHD.

methodsLPS/D-galactosamine (D-GalN) or TNF-α/D-GalN were intraperitoneally injected into C57BL/6J mice to induce ALF. Simultaneously, XJDHD or its individual herbs and components were orally administered. Survival rates, transaminase levels in serum, and hepatic histology were examined to evaluate the effects of XJDHD. The terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay and real-time polymerase chain reaction were additionally performed to expound the mechanism underlying the anti-apoptotic activity of XJDHD.

resultsOral administration of XJDHD protected mice from lethal liver failure induced by LPS and TNF-α, with notable amelioration of liver injury in histology and a significant decrease in transaminase levels in serum. XJDHD significantly inhibited apoptosis of hepatocytes and enhanced expression of the antiapoptosis genes, c-Flip, Iap1, Gadd45b and A20. In addition, Rehmannia glutinosa Libosch. was identified as the key herb of XJDHD and galactose as the effective component of Rehmannia glutinosa Libosch. that protects against ALF.

conclusionsXJDHD inhibits TNF-α-induced apoptosis of hepatocytes by promoting the expression of nuclear factor κ B-regulated anti-apoptotic genes. Rehmannia glutinosa Libosch. is the effective herb of XJDHD and galactose is an active component in this protection.

Indexed as

AnimalsApoptosisCytokinesDrugs, Chinese HerbalGalactosamineHepatocytesLipopolysaccharidesLiver Failure, AcuteMaleMice, Inbred C57BLProtective AgentsRehmanniaTumor Necrosis Factor-alphaCytokinesDrugs, Chinese HerbalGalactosaminelipopolysaccharide BLipopolysaccharidesProtective AgentsTumor Necrosis Factor-alphaacute liver failureChinese medicinelipopolysaccharidesRehmannia glutinosa Libosch.tumor necrosis factor alphaXijiao Dihuang Decoction

Identifiers

PMID26016454
OpenAlexW2241750146

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.