ArticleJournal of materials chemistry. B2015
Fluorescence Imaging of Interscapular Brown Adipose Tissue in Living Mice.
Article in Journal of materials chemistry. B, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Illuminating the metabolic sink: Optical probes for in vivo thermogenic fat imaging.Materials today. Bio · 2026Review
- Mechanism elucidation of cell-selective fluorescent probes.Smart molecules : open access · 2026Article
- A paraventricular hypothalamic control of social stress susceptibility by targeting brown adipose tissue β3 adrenoceptor.Communications biology · 2026Article
- Molecular Afterglow of Lophine-Based Luminophore and Its Imaging Applications.Angewandte Chemie (International ed. in English) · 2025Article
- Wu-Mei-Wan enhances brown adipose tissue function and white adipose browning in obese mice via upregulation of HSF1.Chinese medicine · 2025Article
- Imaging Brown Adipose Tissue with TSPO PET Tracers in Preclinical Animal Studies.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Molecular Tuning of IR-786 for Improved Brown Adipose Tissue Imaging.International journal of molecular sciences · 2022Article
- Quantitative spatial mapping of tissue water and lipid content using spatial frequency domain imaging in the 900- to 1000-nm wavelength region.Journal of biomedical optics · 2022Article
- Molecular Imaging of Brown Adipose Tissue Mass.International journal of molecular sciences · 2021Review
- The nuclear retinoid-related orphan receptor RORα controls adipose tissue inflammation in patients with morbid obesity and diabetes.International journal of obesity (2005) · 2021Article
- Shortwave-infrared meso-patterned imaging enables label-free mapping of tissue water and lipid content.Nature communications · 2020Article
- Imaging adipose tissue browning using the TSPO-18kDa tracer [Molecular metabolism · 2019Article
- Multimodal imaging approach to monitor browning of adipose tissue in vivo.Journal of lipid research · 2018Article
- PET Imaging of Human Brown Adipose Tissue with the TSPO Tracer [Molecular imaging and biology · 2018Article
- Spectral Unmixing Imaging for Differentiating Brown Adipose Tissue Mass and Its Activation.Contrast media & molecular imaging · 2018Article
- Synthesis-free PET imaging of brown adipose tissue and TSPO via combination of disulfiram andScientific reports · 2017Article
- Near-Infrared Photoluminescent Carbon Nanotubes for Imaging of Brown Fat.Scientific reports · 2017Article
- Pre-Assembly of Near-Infrared Fluorescent Multivalent Molecular Probes for Biological Imaging.Bioconjugate chemistry · 2016Article
- PreclinicalFrontiers in pharmacology · 2016Review
- Curcumin analogues as selective fluorescence imaging probes for brown adipose tissue and monitoring browning.Scientific reports · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Brown adipose tissue (BAT) plays a key role in energy expenditure and heat generation and is a promising target for diagnosing and treating obesity, diabetes and related metabolism disorders. While several nuclear and magnetic resonance imaging methods are established for detecting human BAT, there are no convenient protocols for high throughput imaging of BAT in small animal models. Here we disclose a simple but effective method for non-invasive optical imaging of interscapular BAT in mice using a micellar formulation of the commercially available deep-red fluorescent probe, SRFluor680. Whole-body fluorescence imaging of living mice shows extensive accumulation of the fluorescent probe in the interscapular BAT and ex vivo analysis shows 3.5-fold selectivity for interscapular BAT over interscapular WAT. Additional imaging studies indicate that SRFluor680 uptake is independent of mouse species and BAT metabolic state. The results are consistent with an unusual pharmacokinetic process that involves irreversible translocation of the lipophilic SRFluor680 from the micelle nanocarrier into the adipocytes within the BAT. Multimodal PET/CT and planar fluorescence/X-ray imaging of the same living animal shows co-localization of BAT mass signal reported by the fluorescent probe and BAT metabolism signal reported by the PET agent,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.