ArticleInfection and immunity2015
Host-like carbohydrates promote bloodstream survival of Vibrio vulnificus in vivo.
Article in Infection and immunity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 20 citations in OpenAlex.
- Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis.FEBS letters · 2026Article
- Virulent properties and genomic diversity ofMicrobiology spectrum · 2024Article
- How bacteria utilize sialic acid during interactions with the host: snip, snatch, dispatch, match and attach.Microbiology (Reading, England) · 2022Review
- Ecological diversification reveals routes of pathogen emergence in endemicProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Structural and Biosynthetic Diversity of Nonulosonic Acids (NulOs) That Decorate Surface Structures in Bacteria.Trends in microbiology · 2021Review
- Fis Connects Two Sensory Pathways, Quorum Sensing and Surface Sensing, to Control Motility inFrontiers in microbiology · 2021Article
- Chemotactic invasion in deep soft tissue byVirulence · 2020Article
- Structural and functional characterization of CMP-N-acetylneuraminate synthetase from Vibrio cholerae.Acta crystallographica. Section D, Structural biology · 2019Article
- Article
- Identification ofFrontiers in microbiology · 2019Article
- Comprehensive identification of Vibrio vulnificus genes required for growth in human serum.Virulence · 2018Article
- Structural and functional characterization of a modified legionaminic acid involved in glycosylation of a bacterial lipopolysaccharide.The Journal of biological chemistry · 2018Article
- "In-Group" Communication in MarineFrontiers in cellular and infection microbiology · 2018Review
- Article
- Vibrio vulnificus: From Oyster Colonist to Human Pathogen.PLoS pathogens · 2017Review
- Discovery and characterization of de novo sialic acid biosynthesis in the phylum Fusobacterium.Glycobiology · 2016Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sialic acids are found on all vertebrate cell surfaces and are part of a larger class of molecules known as nonulosonic acids. Many bacterial pathogens synthesize related nine-carbon backbone sugars; however, the role(s) of these non-sialic acid molecules in host-pathogen interactions is poorly understood. Vibrio vulnificus is the leading cause of seafood-related death in the United States due to its ability to quickly access the host bloodstream, which it can accomplish through gastrointestinal or wound infection. However, little is known about how this organism persists systemically. Here we demonstrate that sialic acid-like molecules are present on the lipopolysaccharide of V. vulnificus, are required for full motility and biofilm formation, and also contribute to the organism's natural resistance to polymyxin B. Further experiments in a murine model of intravenous V. vulnificus infection demonstrated that expression of nonulosonic acids had a striking benefit for bacterial survival during bloodstream infection and dissemination to other tissues in vivo. In fact, levels of bacterial persistence in the blood corresponded to the overall levels of these molecules expressed by V. vulnificus isolates. Taken together, these results suggest that molecules similar to sialic acids evolved to facilitate the aquatic lifestyle of V. vulnificus but that their emergence also resulted in a gain of function with life-threatening potential in the human host.
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