Evidence map›Paper›PMID 26015293›Full record

ArticleScientific reports2015

Exploiting lipopolysaccharide-induced deformation of lipid bilayers to modify membrane composition and generate two-dimensional geometric membrane array patterns.

Peter G Adams, Kirstie L Swingle, Walter F Paxton, John J Nogan, Loreen R Stromberg, Millicent A Firestone, Harshini Mukundan, Gabriel A Montaño

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Polymerization from Lipid Membranes.Biomacromolecules · 2026
    Article
  3. The Effect of Lipopolysaccharides fromBiomimetics (Basel, Switzerland) · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Peter G AdamsCenter for Integrated Nanotechnologies, Los Alamos National Laboratory, Los Alamos, NM, 87545, USA.
Kirstie L Swingle1] Center for Integrated Nanotechnologies, Los Alamos National Laboratory, Los Alamos, NM, 87545, USA [2] Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA.
Walter F PaxtonCenter for Integrated Nanotechnologies, Sandia National Laboratories, Albuquerque, NM, 87185, USA.
John J NoganCenter for Integrated Nanotechnologies, Sandia National Laboratories, Albuquerque, NM, 87185, USA.
Loreen R StrombergCenter for Biomedical Engineering, University of New Mexico, Albuquerque, NM 87131, USA.
Millicent A FirestoneCenter for Integrated Nanotechnologies, Los Alamos National Laboratory, Los Alamos, NM, 87545, USA.
Harshini Mukundan1] Physical Chemistry and Applied Spectroscopy, Los Alamos National Laboratory, Los Alamos, NM, 87545, USA [2] New Mexico Consortium, Los Alamos, NM, 87545, USA.
Gabriel A MontañoCenter for Integrated Nanotechnologies, Los Alamos National Laboratory, Los Alamos, NM, 87545, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Supported lipid bilayers have proven effective as model membranes for investigating biophysical processes and in development of sensor and array technologies. The ability to modify lipid bilayers after their formation and in situ could greatly advance membrane technologies, but is difficult via current state-of-the-art technologies. Here we demonstrate a novel method that allows the controlled post-formation processing and modification of complex supported lipid bilayer arrangements, under aqueous conditions. We exploit the destabilization effect of lipopolysaccharide, an amphiphilic biomolecule, interacting with lipid bilayers to generate voids that can be backfilled to introduce desired membrane components. We further demonstrate that when used in combination with a single, traditional soft lithography process, it is possible to generate hierarchically-organized membrane domains and microscale 2-D array patterns of domains. Significantly, this technique can be used to repeatedly modify membranes allowing iterative control over membrane composition. This approach expands our toolkit for functional membrane design, with potential applications for enhanced materials templating, biosensing and investigating lipid-membrane processes.

Indexed as

Lipid BilayersLipopolysaccharidesLiposomesMicroarray AnalysisMicroscopy, Atomic ForceMicroscopy, ConfocalPhosphatidylcholines1,2-oleoylphosphatidylcholineLipid BilayersLipopolysaccharidesLiposomesPhosphatidylcholines

Identifiers

PMID26015293
PMCPMC4444833

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.