Observational studyCirculation. Cardiovascular imaging2015
Relationship between alcohol consumption and cardiac structure and function in the elderly: the Atherosclerosis Risk In Communities Study.
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In one paragraph
Observational study in Circulation. Cardiovascular imaging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
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Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- Heart failure with preserved ejection fraction in women: a sex-specific clinical review.The Korean journal of internal medicine · 2026Review
- Analysis of left ventricular mass for African American individuals using multi-ancestry polygenic risk scores: the Jackson Heart Study.Open heart · 2025Article
- Cardiomyopathy in Older Adults.Current cardiology reports · 2025Review
- Cardiac structure and function across the continuum of glucose metabolism.Physiological reports · 2025Article
- Experimental Evaluation of Dose-Dependent Hepatorenal Toxicity of Traditionally Prepared Arak in Swiss Albino Mice.Journal of nutrition and metabolism · 2025Article
- Associations of Alcohol Consumption With Left Atrial Morphology and Function in a Population at High Cardiovascular Risk.Journal of the American Heart Association · 2024Article
- Substance Use-Associated Mortality among Heart Donors after the COVID-19 National Emergency Increased but Did Not Affect Peri-Transplant Outcomes.Journal of cardiovascular development and disease · 2023Article
- Alcohol Consumption and Long-Term Mortality in Men with or without a History of Myocardial Infarction.Journal of atherosclerosis and thrombosis · 2023Article
- Review
- Effect of different alcohol consumption levels on the left atrial size: A cross-sectional study in rural China.Anatolian journal of cardiology · 2022Article
- Sex-specific associations between alcohol consumption, cardiac morphology, and function as assessed by magnetic resonance imaging: insights form the UK Biobank Population Study.European heart journal. Cardiovascular Imaging · 2021Article
- Observational
- Heavy alcohol drinking and subclinical echocardiographic abnormalities of structure and function.Open heart · 2021Article
- Light-moderate alcohol consumption and left ventricular function among healthy, middle-aged adults: the HUNT study.BMJ open · 2018Article
- Global ECG Measures and Cardiac Structure and Function: The ARIC Study (Atherosclerosis Risk in Communities).Circulation. Arrhythmia and electrophysiology · 2018Article
- Genetic Polymorphisms of Alcohol Metabolizing Enzymes and Alcohol Consumption are Associated With Asymptomatic Cardiac Remodeling and Subclinical Systolic Dysfunction in Large Community-Dwelling Asians.Alcohol and alcoholism (Oxford, Oxfordshire) · 2017Article
- Alcohol and cardiovascular disease in the geriatric population.Clinical cardiology · 2017Review
- Race-Related Differences in Left Ventricular Structural and Functional Remodeling in Response to Increased Afterload: The ARIC Study.JACC. Heart failure · 2017Article
- Alcohol's Effects on the Cardiovascular System.Alcohol research : current reviews · 2017Review
- Alcohol Consumption, Left Atrial Diameter, and Atrial Fibrillation.Journal of the American Heart Association · 2016Observational
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 3 countries.
Alexandra GonçalvesFrom the Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (A.G., P.S.J., B.C., A.M.S., S.D.S.); University of Porto Medical School, Porto, Portugal (A.G.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (P.S.J.); Cardiovascular Division, University of Minnesota Medical School, Minneapolis (S.K.); Department of Medicine, University of Mississippi Medical Centre, Jackson (K.B.); Department of Cardiology, Wake Forest School of Medicine, Winston-Salem, NC (D.W.K.); Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill (W.R.); and Division of Cardiology, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil (F.D.F.).
Pardeep S JhundFrom the Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (A.G., P.S.J., B.C., A.M.S., S.D.S.); University of Porto Medical School, Porto, Portugal (A.G.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (P.S.J.); Cardiovascular Division, University of Minnesota Medical School, Minneapolis (S.K.); Department of Medicine, University of Mississippi Medical Centre, Jackson (K.B.); Department of Cardiology, Wake Forest School of Medicine, Winston-Salem, NC (D.W.K.); Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill (W.R.); and Division of Cardiology, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil (F.D.F.).
Brian ClaggettFrom the Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (A.G., P.S.J., B.C., A.M.S., S.D.S.); University of Porto Medical School, Porto, Portugal (A.G.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (P.S.J.); Cardiovascular Division, University of Minnesota Medical School, Minneapolis (S.K.); Department of Medicine, University of Mississippi Medical Centre, Jackson (K.B.); Department of Cardiology, Wake Forest School of Medicine, Winston-Salem, NC (D.W.K.); Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill (W.R.); and Division of Cardiology, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil (F.D.F.).
Amil M ShahFrom the Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (A.G., P.S.J., B.C., A.M.S., S.D.S.); University of Porto Medical School, Porto, Portugal (A.G.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (P.S.J.); Cardiovascular Division, University of Minnesota Medical School, Minneapolis (S.K.); Department of Medicine, University of Mississippi Medical Centre, Jackson (K.B.); Department of Cardiology, Wake Forest School of Medicine, Winston-Salem, NC (D.W.K.); Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill (W.R.); and Division of Cardiology, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil (F.D.F.).
Suma KonetyFrom the Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (A.G., P.S.J., B.C., A.M.S., S.D.S.); University of Porto Medical School, Porto, Portugal (A.G.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (P.S.J.); Cardiovascular Division, University of Minnesota Medical School, Minneapolis (S.K.); Department of Medicine, University of Mississippi Medical Centre, Jackson (K.B.); Department of Cardiology, Wake Forest School of Medicine, Winston-Salem, NC (D.W.K.); Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill (W.R.); and Division of Cardiology, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil (F.D.F.).
Kenneth ButlerFrom the Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (A.G., P.S.J., B.C., A.M.S., S.D.S.); University of Porto Medical School, Porto, Portugal (A.G.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (P.S.J.); Cardiovascular Division, University of Minnesota Medical School, Minneapolis (S.K.); Department of Medicine, University of Mississippi Medical Centre, Jackson (K.B.); Department of Cardiology, Wake Forest School of Medicine, Winston-Salem, NC (D.W.K.); Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill (W.R.); and Division of Cardiology, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil (F.D.F.).
Dalane W KitzmanFrom the Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (A.G., P.S.J., B.C., A.M.S., S.D.S.); University of Porto Medical School, Porto, Portugal (A.G.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (P.S.J.); Cardiovascular Division, University of Minnesota Medical School, Minneapolis (S.K.); Department of Medicine, University of Mississippi Medical Centre, Jackson (K.B.); Department of Cardiology, Wake Forest School of Medicine, Winston-Salem, NC (D.W.K.); Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill (W.R.); and Division of Cardiology, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil (F.D.F.).
Wayne RosamondFrom the Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (A.G., P.S.J., B.C., A.M.S., S.D.S.); University of Porto Medical School, Porto, Portugal (A.G.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (P.S.J.); Cardiovascular Division, University of Minnesota Medical School, Minneapolis (S.K.); Department of Medicine, University of Mississippi Medical Centre, Jackson (K.B.); Department of Cardiology, Wake Forest School of Medicine, Winston-Salem, NC (D.W.K.); Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill (W.R.); and Division of Cardiology, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil (F.D.F.).
Flavio D FuchsFrom the Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (A.G., P.S.J., B.C., A.M.S., S.D.S.); University of Porto Medical School, Porto, Portugal (A.G.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (P.S.J.); Cardiovascular Division, University of Minnesota Medical School, Minneapolis (S.K.); Department of Medicine, University of Mississippi Medical Centre, Jackson (K.B.); Department of Cardiology, Wake Forest School of Medicine, Winston-Salem, NC (D.W.K.); Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill (W.R.); and Division of Cardiology, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil (F.D.F.).
Scott D SolomonFrom the Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (A.G., P.S.J., B.C., A.M.S., S.D.S.); University of Porto Medical School, Porto, Portugal (A.G.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (P.S.J.); Cardiovascular Division, University of Minnesota Medical School, Minneapolis (S.K.); Department of Medicine, University of Mississippi Medical Centre, Jackson (K.B.); Department of Cardiology, Wake Forest School of Medicine, Winston-Salem, NC (D.W.K.); Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill (W.R.); and Division of Cardiology, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil (F.D.F.). ssolomon@rics.bwh.harvard.edu.
University of Minnesota Medical Center · USUniversity of Mississippi Medical Center · USUniversity of North Carolina at Chapel Hill · USWake Forest University · USUniversidade do Porto · PTUniversity of Glasgow · GB
Funding
Systolic & diastolic dysfunction in heart failure and preserved ejection fractionK08HL116792 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SHAH, AMIL M · 2013 to 2017
$735kNHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS K08 HL116792
Abstract
backgroundExcessive alcohol consumption is associated with cardiomyopathy, but the influence of moderate alcohol use on cardiac structure and function is largely unknown. METHODS AND
resultsWe studied 4466 participants from visit 5 of the Atherosclerosis Risk in Communities (ARIC) study (76±5 years and 60% women) who underwent transthoracic echocardiography, excluding former drinkers and those with significant valvular disease. Participants were classified into 4 categories based on self-reported alcohol intake: nondrinkers, drinkers of ≤7, ≥7 to 14, and ≥14 drinks per week. We related alcohol intake to measures of cardiac structure and function, stratified by sex, and fully adjusted for covariates. In both genders, increasing alcohol intake was associated with larger left ventricular diastolic and systolic diameters and larger left atrial diameter (P<0.05). In men, increasing alcohol intake was associated with greater left ventricular mass (8.2±3.8 g per consumption category; P=0.029) and higher E/E' ratio (0.82±0.33 per consumption category; P=0.014). In women, increasing alcohol intake was associated with lower left ventricular ejection fraction (-1.9±0.6% per consumption category; P=0.002) and a tendency for worse left ventricular global longitudinal strain (0.45±0.25% per consumption category; P=0.07).
conclusionsIn an elderly community-based population, increasing alcohol intake is associated with subtle alterations in cardiac structure and function, with women appearing more susceptible than men to the cardiotoxic effects of alcohol.
Indexed as
AgedAlcohol DrinkingAtherosclerosisCardiomyopathiesCausalityComorbidityFemaleHeartHeart AtriaHeart VentriclesHumansMaleProspective StudiesRiskRisk FactorsSex Factorsalcohol drinkingcardiomyopathiesechocardiographyheart failurepopulation
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