ArticleBiochimica et biophysica acta2015
Effect of surface-potential modulators on the opening of lipid pores in liposomal and mitochondrial inner membranes induced by palmitate and calcium ions.
Article in Biochimica et biophysica acta, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 14 citations in OpenAlex.
- Aging-Related and Gender Specific Albumin Misfolding in Alzheimer's Disease.Journal of Alzheimer's disease reports · 2020Article
- Probing the effect of a room temperature ionic liquid on phospholipid membranes in multilamellar vesicles.European biophysics journal : EBJ · 2019Article
- Computational models for monitoring the trans-membrane potential with fluorescent probes: the DiSCEuropean biophysics journal : EBJ · 2016Article
- Effects of Phospholipase A2 Inhibitors on Bilayer Lipid Membranes.The Journal of membrane biology · 2016Article
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7 authors at 4 institutions in 2 countries.
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Abstract
The effect of surface-potential modulators on palmitate/Ca2+-induced formation of lipid pores was studied in liposomal and inner mitochondrial membranes. Pore formation was monitored by sulforhodamine B release from liposomes and swelling of mitochondria. ζ-potential in liposomes was determined from electrophoretic mobility. Replacement of sucrose as the osmotic agent with KCl decreased negative ζ-potential in liposomes and increased resistance of both mitochondria and liposomes to the pore inducers, palmitic acid, and Ca2+. Micromolar Mg2+ also inhibited palmitate/Ca2+-induced permeabilization of liposomes. The rate of palmitate/Ca2+-induced, cyclosporin A-insensitive swelling of mitochondria increased 22% upon increasing pH from 7.0 to 7.8. At below the critical micelle concentration, the cationic detergent cetyltrimethylammonium bromide (10 μM) and the anionic surfactant sodium dodecylsulfate (10-50 μM) made the ζ-potential less and more negative, respectively, and inhibited and stimulated opening of mitochondrial palmitate/Ca2+-induced lipid pores. Taken together, the findings indicate that surface potential regulates palmitate/Ca2+-induced lipid pore opening.
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