ArticleEuropean journal of human genetics : EJHG2016
Myelination-related genes are associated with decreased white matter integrity in schizophrenia.
Article in European journal of human genetics : EJHG, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- A model of free sialic acid storage disorder reveals hypomyelinating leukodystrophy and Purkinje cell degeneration.Disease models & mechanisms · 2026Article
- The Peripheral Epigenome Predicts White Matter Volume Contingent on Developmental Stage: An ECHO Study.Molecular neurobiology · 2025Article
- Altered N170 and compensatory mechanisms in face processing in schizophrenia: an event-related potential study.Frontiers in psychiatry · 2025Article
- Dysregulation of myelination-related genes in schizophrenia.Journal of neurochemistry · 2024Review
- Quantitative susceptibility mapping in the brain reflects spatial expression of genes involved in iron homeostasis and myelination.Human brain mapping · 2024Article
- Editorial: Journey to the Center of the Brain: Cell Physiology and Intercellular Communication in White Matter.Frontiers in cellular neuroscience · 2022Article
- Multi-band network fusion for Alzheimer's disease identification with functional MRI.Frontiers in psychiatry · 2022Article
- White matter microstructure in women with acute and remitted anorexia nervosa: an exploratory neuroimaging study.Brain imaging and behavior · 2020Article
- Genetic Variation in CNS Myelination and Functional Brain Connectivity in Recombinant Inbred Mice.Cells · 2020Article
- Major Neuropsychological Impairments in Schizophrenia Patients: Clinical Implications.Current psychiatry reports · 2020Review
- White matter loss and oligodendrocyte dysfunction in HIV: A consequence of the infection, the antiretroviral therapy or both?Brain research · 2019Review
- Candidate CSPG4 mutations and induced pluripotent stem cell modeling implicate oligodendrocyte progenitor cell dysfunction in familial schizophrenia.Molecular psychiatry · 2019Article
- Developmental Changes in Oligodendrocyte Genesis, Myelination, and Associated Behavioral Dysfunction in a Rat Model of Intra-generational Protein Malnutrition.Molecular neurobiology · 2019Article
- White matter aberrations and age-related trajectories in patients with schizophrenia and bipolar disorder revealed by diffusion tensor imaging.Scientific reports · 2018Article
- Bad wrap: Myelin and myelin plasticity in health and disease.Developmental neurobiology · 2018Review
- Validation of a microRNA target site polymorphism in H3F3B that is potentially associated with a broad schizophrenia phenotype.PloS one · 2018Article
- Age-Related Changes in Topological Degradation of White Matter Networks and Gene Expression in Chronic Schizophrenia.Brain connectivity · 2017Article
- Gene-set analysis shows association between FMRP targets and autism spectrum disorder.European journal of human genetics : EJHG · 2017Article
- BACE1-Dependent Neuregulin-1 Signaling: An Implication for Schizophrenia.Frontiers in molecular neuroscience · 2017Review
- Myelination of parvalbumin interneurons: a parsimonious locus of pathophysiological convergence in schizophrenia.Molecular psychiatry · 2017Review
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Authors and funding
14 authors at 7 institutions in 3 countries.
Funding
Abstract
Disruptions in white matter (WM) tract structures have been implicated consistently in the pathophysiology of schizophrenia. Global WM integrity--as measured by fractional anisotropy (FA)--is highly heritable and may provide a good endophenotype for genetic studies of schizophrenia. WM abnormalities in schizophrenia are not localized to one specific brain region but instead reflect global low-level decreases in FA coupled with focal abnormalities. In this study, we sought to investigate whether functional gene sets associated with schizophrenia are also associated with WM integrity. We analyzed FA and genetic data from the Mind Research Network Clinical Imaging Consortium to study the effect of multiple oligodendrocyte gene sets on schizophrenia and WM integrity using a functional gene set analysis in 77 subjects with schizophrenia and 104 healthy controls. We found that a gene set involved in myelination was significantly associated with schizophrenia and FA. This gene set includes 17 genes that are expressed in oligodendrocytes and one neuronal gene (NRG1) that is known to regulate myelination. None of the genes within the gene set were associated with schizophrenia or FA individually, suggesting that no single gene was driving the association of the gene set. Our findings support the hypothesis that multiple genetic variants in myelination-related genes contribute to the observed correlation between schizophrenia and decreased WM integrity as measured by FA.
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Registered trials
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