Evidence map›Paper›PMID 26013832›Full record

ArticleThe Journal of biological chemistry2015

Osteonecrosis of the Jaw Developed in Mice: DISEASE VARIANTS REGULATED BY γδ T CELLS IN ORAL MUCOSAL BARRIER IMMUNITY.

Sil Park, Keiichi Kanayama, Kawaljit Kaur, Han-Ching Helen Tseng, Sina Banankhah, Davood Talebi Quje, James W Sayre, Anahid Jewett, Ichiro Nishimura

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 59 citations in OpenAlex.

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  13. Review
  14. Immune Dysfunction in Medication-Related Osteonecrosis of the Jaw.International journal of molecular sciences · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Sil ParkFrom the Weintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics and Division of Oral Biology and Medicine, UCLA School of Dentistry, Los Angeles, California 90095.
Keiichi KanayamaFrom the Weintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics and the Department of Periodontology, Asahi University School of Dentistry, Gifu 501-0296, Japan, and.
Kawaljit KaurDivision of Oral Biology and Medicine, UCLA School of Dentistry, Los Angeles, California 90095.
Han-Ching Helen TsengDivision of Oral Biology and Medicine, UCLA School of Dentistry, Los Angeles, California 90095.
Sina BanankhahFrom the Weintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics and.
Davood Talebi QujeFrom the Weintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics and.
James W Sayrethe Department of Biostatistics, UCLA Fielding School of Public Health, Los Angeles, California 90095.
Anahid JewettDivision of Oral Biology and Medicine, UCLA School of Dentistry, Los Angeles, California 90095.
Ichiro NishimuraFrom the Weintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics and Division of Oral Biology and Medicine, UCLA School of Dentistry, Los Angeles, California 90095, inishimura@dentistry.ucla.edu.
University of California, Los Angeles · USAsahi University · JPUCLA Health · US

Funding

Oral Mucosa Barrier and Bisphosphonate-related Osteonecrosis of the JawR01DE022552 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NISHIMURA, ICHIRO · 2012 to 2016
$2.2M
EXTRAMURAL RESEARCH FACILITIES CONSTRUCTION PROJECTSC06RR014529 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PARK, NO-HEE · 1999 to 1999
–
NCRR NIH HHS C06 RR014529NIDCR NIH HHS R01 DE022552
6 · The paper itself

Abstract

Osteonecrosis of the jaw (ONJ), an uncommon co-morbidity in patients treated with bisphosphonates (BP), occurs in the segment of jawbone interfacing oral mucosa. This study aimed to investigate a role of oral mucosal barrier γδ T cells in the pathogenesis of ONJ. Female C57Bl/6J (B6) mice received a bolus zoledronate intravenous injection (ZOL, 540 μg/kg), and their maxillary left first molars were extracted 1 week later. ZOL-treated mice (WT ZOL) delayed oral wound healing with patent open wounds 4 weeks after tooth extraction with characteristic oral epithelial hyperplasia. γδ T cells appeared within the tooth extraction site and hyperplastic epithelium in WT ZOL mice. In ZOL-treated γδ T cell null (Tcrd(-/-) ZOL) mice, the tooth extraction open wound progressively closed; however, histological ONJ-like lesions were identified in 75 and 60% of WT ZOL and Tcrd(-/-) ZOL mice, respectively. Although the bone exposure phenotype of ONJ was predominantly observed in WT ZOL mice, Tcrd(-/-) ZOL mice developed the pustule/fistula disease phenotype. We further addressed the role of γδ T cells from human peripheral blood (h-γδ T cells). When co-cultured with ZOL-pretreated human osteoclasts in vitro, h-γδ T cells exhibited rapid expansion and robust IFN-γ secretion. When h-γδ T cells were injected into ZOL-treated immunodeficient (Rag2(-/-) ZOL) mice, the oral epithelial hyperplasia developed. However, Rag2(-/-) ZOL mice did not develop osteonecrosis. The results indicate that γδ T cells are unlikely to influence the core osteonecrosis mechanism; however, they may serve as a critical modifier contributing to the different oral mucosal disease variations of ONJ.

Indexed as

Immunity, MucosalAnimalsBisphosphonate-Associated Osteonecrosis of the JawBone Density Conservation AgentsDiphosphonatesDisease Models, AnimalDNA-Binding ProteinsFemaleHumansImidazolesIn Vitro TechniquesJawMiceMice, Inbred C57BLMice, KnockoutMouth MucosaBone Density Conservation AgentsDiphosphonatesDNA-Binding ProteinsImidazolesRag2 protein, mouseReceptors, Antigen, T-Cell, gamma-deltaZoledronic Acidbisphosphonatemousemucosal immunologyONJosteonecrosispathogenesisT cellwound healingγδ T cells

Identifiers

PMID26013832
PMCPMC4498073
OpenAlexW1523848206

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.