Evidence map›Paper›PMID 26013798›Full record

ArticleImmunologic research2015

Practical NK cell phenotyping and variability in healthy adults.

Laura S Angelo, Pinaki P Banerjee, Linda Monaco-Shawver, Joshua B Rosen, George Makedonas, Lisa R Forbes, Emily M Mace, Jordan S Orange

Open access · greenAbstract read
In one paragraph

Article in Immunologic research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 130 citations in OpenAlex.

  1. Review
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  11. The clinical landscape of CAR NK cells.Experimental hematology & oncology · 2025
    Review
  12. Article
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  16. DOGMA-seq and multimodal, single-cell analysis in acute myeloid leukemia.International review of cell and molecular biology · 2025
    Review
  17. Article
  18. Article
  19. Review
  20. Review

32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Laura S AngeloCenter for Human Immunobiology, Department of Allergy, Immunology and Rheumatology, The Feigin Center, Texas Children's Hospital, 1102 Bates Street, Suite 330, Houston, TX, 77030, USA, laura.angelo@bcm.edu.
Pinaki P Banerjee
Linda Monaco-Shawver
Joshua B Rosen
George Makedonas
Lisa R Forbes
Emily M Mace
Jordan S Orange
Baylor College of Medicine · USChildren's Hospital of Philadelphia · USDrexel University · USTexas Children's Hospital · US

Funding

Virology CoreP30AI036211 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI BUTEL, JANET S · 1994 to 2015
$21.7M
Directing Function at the Natural Killer Cell Secretory Immunological SynapseR01AI067946 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ORANGE, JORDAN SCOTT · 2007 to 2019
$4.8M
Directing Function at the Natural Killer Cell Secretory Immunological SynapseR37AI067946 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Jordan Scott Orange · 2024 to 2026
$1.5M
NIAID NIH HHS P30 AI036211NIAID NIH HHS R01 AI067946NIAID NIH HHS R37 AI067946
6 · The paper itself

Abstract

Human natural killer (NK) cells display a wide array of surface and intracellular markers that indicate various states of differentiation and/or levels of effector function. These NK cell subsets exist simultaneously in peripheral blood and may vary among individuals. We examined variety among selected NK cell receptors expressed by NK cells from normal donors, as well as the distribution of select NK cell subsets and NK cell receptor expression over time in several individual donors. Peripheral blood mononuclear cells were evaluated using flow cytometry via fluorochrome-conjugated antibodies against a number of NK cell receptors. Results were analyzed for both mean fluorescence intensity (MFI) and the percent positive cells for each receptor. CD56(bright) and CD56(dim) NK cell subsets were also considered separately, as was variation in receptor expression in NK cell subsets over time in selected individuals. Through this effort, we provide ranges of NK cell surface receptor expression for a local adult population as well as provide insight into intra-individual variation.

Indexed as

AdultCD56 AntigenFlow CytometryHumansImmunophenotypingKiller Cells, NaturalLeukocytes, MononuclearLymphocyte SubsetsReceptors, Cell SurfaceCD56 AntigenNCAM1 protein, humanReceptors, Cell Surface

Identifiers

PMID26013798
PMCPMC4470870
OpenAlexW355948156

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.