Evidence map›Paper›PMID 26013768›Full record

ArticleCancer epidemiology2015

Comparison of cumulative false-positive risk of screening mammography in the United States and Denmark.

Katja Kemp Jacobsen, Linn Abraham, Diana S M Buist, Rebecca A Hubbard, Ellen S O'Meara, Brian L Sprague, Karla Kerlikowske, Ilse Vejborg, My Von Euler-Chelpin, Sisse Helle Njor

Open access · greenAbstract readComparative Study
In one paragraph

Article in Cancer epidemiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
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  5. Statistical Methods for Estimating the Cumulative Risk of Screening Mammography Outcomes.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2016
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Katja Kemp JacobsenDepartment of Public Health, University of Copenhagen, Copenhagen K, Denmark. Electronic address: kkja@sund.ku.dk.
Linn AbrahamGroup Health Research Institute, Seattle, WA, United States.
Diana S M BuistGroup Health Research Institute, Seattle, WA, United States.
Rebecca A HubbardDepartment of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, United States.
Ellen S O'MearaGroup Health Research Institute, Seattle, WA, United States.
Brian L SpragueDepartment of Surgery, University of Vermont, Burlington, VT, United States.
Karla KerlikowskeDepartment of Epidemiology & Biostatistics, University of California, San Francisco, CA, United States; General Internal Medicine Section, Department of Veterans Affairs, University of California, San Francisco, CA, United States.
Ilse VejborgCenter of Diagnostic Imaging, Copenhagen University Hospital, Rigshospitalet, Denmark.
My Von Euler-ChelpinDepartment of Public Health, University of Copenhagen, Copenhagen K, Denmark.
Sisse Helle NjorDepartment of Public Health, University of Copenhagen, Copenhagen K, Denmark.
Kaiser Permanente Washington Health Research Institute · USUniversity of Copenhagen · DKCopenhagen University Hospital · DKSan Francisco VA Medical Center · USUniversity of Pennsylvania · USUniversity of Vermont · US

Funding

Risk-based Imaging Strategies to Improve Breast Cancer Surveillance OutcomesP01CA154292 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Diana L Miglioretti · 2011 to 2026
$52.9M
Vermont Screening Process Documentation UnitU54CA163303 · NCI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI SPRAGUE, BRIAN L · 2011 to 2017
$6.4M
Statistical Methods for Estimation of Benefits & Harms of Repeat Cancer ScreeningR03CA182986 · NCI · UNIVERSITY OF PENNSYLVANIA · PI HUBBARD, REBECCA · 2014 to 2015
$160k
NCI NIH HHS HHSN261201100031CNCI NIH HHS P01 CA154292NCI NIH HHS P01CA154292NCI NIH HHS R03 CA182986NCI NIH HHS R03CA182986NCI NIH HHS U54 CA163303NCI NIH HHS U54CA163303
6 · The paper itself

Abstract

introductionIn the United States (US), about one-half of women screened with annual mammography have at least one false-positive test after ten screens. The estimate for European women screened ten times biennially is much lower. We evaluate to what extent screening interval, mammogram type, and statistical methods, can explain the reported differences.

methodsWe included all screens from women first screened at age 50-69 years in the US Breast Cancer Surveillance Consortium (BCSC) (n=99,455) between 1996-2010, and from two population-based mammography screening programs in Denmark (n=230,452 and n=400,204), between 1991-2012 and 1993-2013, respectively. Model-based cumulative false-positive risks were computed for the entire sample, using two statistical methods (Hubbard Njor) previously used to estimate false-positive risks in the US and Europe.

resultsEmpirical cumulative risk of at least one false-positive test after eight (annual or biennial) screens was 41.9% in BCSC, 16.1% in Copenhagen, and 7.4% in Funen. Variation in screening interval and mammogram type did not explain the differences by country. Using the Hubbard method, the model-based cumulative risks after eight screens was 45.1% in BCSC, 9.6% in Copenhagen, and 8.8% in Funen. Using the Njor method, these risks were estimated to be 43.6, 10.9 and 8.0%.

conclusionChoice of statistical method, screening interval and mammogram type does not explain the substantial differences in cumulative false-positive risk between the US and Europe.

Indexed as

Early Detection of CancerMammographyAgedBreast NeoplasmsDenmarkFalse Positive ReactionsFemaleHumansMiddle AgedRiskUnited StatesBreast neoplasmFalse-positive reactionsMammographyMass screeningMethods

Identifiers

PMID26013768
PMCPMC4871241
OpenAlexW1603266686

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.