ArticleThe American journal of tropical medicine and hygiene2015
The Influence of Mining and Human Immunodeficiency Virus Infection Among Patients Admitted for Retreatment of Tuberculosis in Northern Tanzania.
Article in The American journal of tropical medicine and hygiene, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Prevalence and factors associated with tuberculosis among the mining communities in Mererani, Tanzania.PloS one · 2023Article
- High mortality during tuberculosis retreatment at a Ghanaian tertiary center: a retrospective cohort study.The Pan African medical journal · 2019Article
- Identification of Risk Factors of Multidrug-Resistant Tuberculosis by using Classification Tree Method.The American journal of tropical medicine and hygiene · 2017Article
- Risk factors for the treatment outcome of retreated pulmonary tuberculosis patients in China: an optimized prediction model.Epidemiology and infection · 2017Article
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5 authors.
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Abstract
In tuberculosis (TB)-prevalent settings, patients admitted for retreatment of TB may account for a high burden of poor treatment outcome. We performed a retrospective cohort study to characterize retreatment patients and outcomes at a TB referral hospital in northern Tanzania. From 2009 to 2013, 185 patients began a retreatment regimen, the majority for relapse after prior treatment completion. Men accounted for an unexpected majority (88%), 36 (20%) were human immunodeficiency virus (HIV) infected and for 45 (24%) mining was their primary occupation. A poor outcome (death, default, or persistent smear positivity after 7 months of treatment) was found in 37 (23%). HIV infection was the only significant predictor of poor outcome (adjusted odds ratio [aOR] = 2.50, 95% confidence interval [CI] = 1.07-5.83, P = 0.034). Interventions to minimize need for retreatment or improve retreatment success may be regionally specific. In our setting, community-based diagnosis and management among at-risk subpopulations such as miners and those HIV infected appear of highest yield.
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