Evidence map›Paper›PMID 26013051›Full record

Trial reportEuropean journal of applied physiology2015

The effects of high intensity interval training in women with rheumatic disease: a pilot study.

Janne Sandstad, Dorthe Stensvold, Mari Hoff, Bjarne M Nes, Ingerid Arbo, Anja Bye

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of applied physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01478334 (Exercise-induced Improvements of Inflammatory Status in Patients With Rheumatoid Arthritis - Improvements of Cardiovascular Risk Factors and Quality of Life), which is not on this map. Cited by 30 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 5 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01478334 nacompletednot on this map

Exercise-induced Improvements of Inflammatory Status in Patients With Rheumatoid Arthritis - Improvements of Cardiovascular Risk Factors and Quality of Life

TypeinterventionalSponsorNorwegian University of Science and TechnologyRan2011 to 2012Enrolled18ConditionsRheumatoid ArthritisArmshigh intensity interval training, Control
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 5 syntheses or guidelines pooled it, 53 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Janne SandstadDepartment of Circulation and Medical Imaging, Faculty of Medicine, Medical Technology Research Centre, KG Jebsen Center of Exercise in Medicine, Norwegian University of Science and Technology (NTNU), P.O. box 8905, 7491, Trondheim, Norway.
Dorthe StensvoldDepartment of Circulation and Medical Imaging, Faculty of Medicine, Medical Technology Research Centre, KG Jebsen Center of Exercise in Medicine, Norwegian University of Science and Technology (NTNU), P.O. box 8905, 7491, Trondheim, Norway.
Mari HoffDepartment of Rheumatology, St. Olavs Hospital, Trondheim, Norway.
Bjarne M NesDepartment of Circulation and Medical Imaging, Faculty of Medicine, Medical Technology Research Centre, KG Jebsen Center of Exercise in Medicine, Norwegian University of Science and Technology (NTNU), P.O. box 8905, 7491, Trondheim, Norway.
Ingerid ArboDepartment of Circulation and Medical Imaging, Faculty of Medicine, Medical Technology Research Centre, KG Jebsen Center of Exercise in Medicine, Norwegian University of Science and Technology (NTNU), P.O. box 8905, 7491, Trondheim, Norway.
Anja ByeDepartment of Circulation and Medical Imaging, Faculty of Medicine, Medical Technology Research Centre, KG Jebsen Center of Exercise in Medicine, Norwegian University of Science and Technology (NTNU), P.O. box 8905, 7491, Trondheim, Norway. Anja.Bye@ntnu.no.
Norwegian University of Science and Technology · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeRheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) are inflammatory diseases which involve increased risk of cardiovascular disease (CVD). High intensity interval training (HIIT) is known to be effective in improving cardiovascular health. The aim of this study was to investigate whether 10 weeks of HIIT at 85-95% of HRmax would improve important risk factors of CVD in rheumatic patients, and if these patients would tolerate exercise intensities above today's recommendations.

methodsSeven women with RA and eleven with adult-JIA, 20-50 years, were recruited to this cross-over study. Participants performed HIIT, consisting of 4 × 4 min intervals at 85-95% of HRmax twice a week for 10 weeks on spinning bikes. Maximal oxygen uptake (VO2max), heart rate recovery, blood pressure, body composition, and blood variables were measured before and after the exercise and control period. Disease activity was determined and questionnaire data were collected.

resultsHIIT resulted in 12.2% increase in VO2max and 2.9% improvement in heart rate recovery (p < 0.05). BMI, body fat, and waist circumference decreased 1.2, 1.0, and 1.6%, respectively, whereas muscle mass increased 0.6% (p < 0.05). A trend toward decreased CRP was detected after HIIT (p = 0.08). No changes were detected in disease activity or pain.

conclusionDespite rigorous high intensity exercise, no increase was detected in disease activity or pain, indicating that HIIT was well tolerated by these patients. Furthermore, HIIT had positive effects on several CVD risk factors. In light of this pilot study, HIIT seems like a promising non-pharmacological treatment strategy for patients with RA and adult-JIA.

Indexed as

AdultArthritis, JuvenileArthritis, RheumatoidExercise TherapyFemaleHeart RateHumansMiddle AgedResistance TrainingCardiovascular diseasesExerciseRheumatology

Identifiers

PMID26013051
OpenAlexW1899133742

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.