Evidence map›Paper›PMID 26012740›Full record

ArticleInternational health2015

Pregnant women with HIV in rural Nigeria have higher rates of antiretroviral treatment initiation, but similar loss to follow-up as non-pregnant women and men.

Muktar H Aliyu, Meridith Blevins, Karen M Megazzini, Deidra D Parrish, Carolyn M Audet, Naomi Chan, Chisom Odoh, Usman I Gebi, Mukhtar Y Muhammad, Bryan E Shepherd and 2 more

Abstract read
In one paragraph

Article in International health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Muktar H AliyuVanderbilt Institute for Global Health Departments of Health Policy muktar.aliyu@vanderbilt.edu.
Meridith BlevinsVanderbilt Institute for Global Health Department of Biostatistics.
Karen M MegazziniWestat, Rockville, MD, USA.
Deidra D ParrishVanderbilt Institute for Global Health Departments of Health Policy.
Carolyn M AudetVanderbilt Institute for Global Health Departments of Health Policy.
Naomi ChanVanderbilt Institute for Global Health Department of Human and Organizational Development.
Chisom OdohDepartment of Health Administration and Health Sciences, Tennessee State University, 330 10th Avenue North, Suite D-400, Nashville, TN 37203, USA.
Usman I GebiFriends for Global Health Initiative, Abuja, Nigeria.
Mukhtar Y MuhammadFriends for Global Health Initiative, Abuja, Nigeria.
Bryan E ShepherdVanderbilt Institute for Global Health Department of Biostatistics.
C William WesterVanderbilt Institute for Global Health Department of Medicine.
Sten H VermundVanderbilt Institute for Global Health Department of Pediatrics, Vanderbilt University, 2525 West End Avenue, Suite 750, Nashville, TN 37203, USA.

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Fogarty International Clinical Research Scholars Support Center @ Vanderbilt-AAMCR24TW007988 · FIC · VANDERBILT UNIVERSITY · PI VERMUND, STEN H. · 2007 to 2011
$27.6M
Tennessee CFAR: Implementation of Culturally Responsive Trauma-Informed Care with Youth with HIV in Memphis, TNP30AI110527 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI APRIL PETTIT · 2015 to 2026
$27.5M
Optimizing integrated PMTCT services in rural North-Central NigeriaR01HD075075 · NICHD · VANDERBILT UNIVERSITY · PI ALIYU, MUKTAR HASSAN · 2012 to 2013
$895k
Traditional Healers as Adherence Partners for PLHIV in Rural MozambiqueK01MH107255 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI AUDET, CAROLYN · 2015 to 2018
$658k
FIC NIH HHS R24 TW007988FIC NIH HHS R24TW007988NCATS NIH HHS KL2TR000445NCATS NIH HHS UL1 TR000445NIAID NIH HHS P30 AI110527NICHD NIH HHS R01 HD075075NICHD NIH HHS R01HD075075NIMH NIH HHS K01 MH107255
6 · The paper itself

Abstract

backgroundWe examined antiretroviral therapy (ART) initiation and retention by sex and pregnancy status in rural Nigeria.

methodsWe studied HIV-infected ART-naïve patients aged ≥15 years entering care from June 2009 to September 2013. We calculated the probability of early ART initiation and cumulative incidence of loss to follow-up (LTFU) during the first year of ART, and examined the association between LTFU and sex/pregnancy using Cox regression.

resultsThe cohort included 3813 ART-naïve HIV-infected adults (2594 women [68.0%], 273 [11.8%] of them pregnant). The proportion of pregnant clients initiating ART within 90 days of enrollment (78.0%, 213/273) was higher than among non-pregnant women (54.3%,1261/2321) or men (53.0%, 650/1219), both p<0.001. Pregnant women initiated ART sooner than non-pregnant women and men (median [IQR] days from enrollment to ART initiation for pregnant women=7 days [0-21] vs 14 days [7-49] for non-pregnant women and 14 days [7-42] for men; p<0.001). Cumulative incidence of LTFU during the first year post-ART initiation was high and did not differ by sex and pregnancy status. Persons who were unemployed, bedridden, had higher CD4+ counts, and/or in earlier WHO clinical stages were more likely to be LTFU.

conclusionsPregnant women with HIV in rural Nigeria were more likely to initiate ART but were no more likely to be retained in care. Our findings underscore the importance of effective retention strategies across all patient groups, regardless of sex and pregnancy status.

Indexed as

AdolescentAdultAnti-Retroviral AgentsCD4 Lymphocyte CountFemaleFollow-Up StudiesHIV InfectionsHumansIncidenceMaleNigeriaPatient DropoutsPregnancyRural PopulationSex FactorsSocioeconomic FactorsAnti-Retroviral AgentsAntiretroviral therapyHIV/AIDSLoss to follow-upNigeriaRetention in care

Identifiers

PMID26012740
PMCPMC4654753

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.