ArticleBreast cancer research and treatment2015
Racial and ethnic differences in risk of second primary cancers among breast cancer survivors.
Article in Breast cancer research and treatment, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 26 citations in OpenAlex.
- Risk factors for second primary cancer in patients who survive breast cancer.NPJ breast cancer · 2026Article
- Immigration and Social Factors, Tumor Stage, and Risk of Contralateral Breast Cancer in Asian American and Hispanic Women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026Article
- Overall and central adiposity and risk of contralateral breast cancer: The California Breast Cancer Survivorship Consortium.International journal of cancer · 2026Article
- County-level socioeconomic status, rurality, and second primary cancer risk among breast cancer survivors in the United States.Cancer causes & control : CCC · 2025Article
- Article
- Second primary non-breast cancers in young breast cancer survivors.Breast cancer research and treatment · 2024Article
- Second primary cancer risks according to race and ethnicity among U.S. breast cancer survivors.International journal of cancer · 2024Article
- Variation in patterns of second primary malignancies across U.S. race and ethnicity groups: a Surveillance, Epidemiology, and End Results (SEER) analysis.Cancer causes & control : CCC · 2024Article
- Routine clinical parameters and laboratory testing predict therapy-related myeloid neoplasms after treatment for breast cancer.Haematologica · 2023Article
- Risk of secondary malignancy after radiotherapy for breast cancer: long-term follow-up of Japanese patients with breast cancer.Breast cancer research and treatment · 2022Article
- Treatment-related sequelae in Hodgkin's lymphoma after mediastinal irradiation.International journal of hematology · 2022Article
- Relationship between metastasis and second primary cancers in women with breast cancer.Frontiers in oncology · 2022Article
- Article
- Race, ethnicity and risk of second primary contralateral breast cancer in the United States.International journal of cancer · 2021Article
- Article
- Survival and chemotherapy-related risk of second primary malignancy in breast cancer patients: a SEER-based study.International journal of clinical oncology · 2019Article
- Health Behaviors and Lifestyle Interventions in African American Breast Cancer Survivors: A Review.Frontiers in oncology · 2019Review
- Breast Cancer Outcomes in a Racially and Ethnically Diverse Cohort of Insured Women.Ethnicity & disease · 2018Article
- Identification of Biomarkers for Breast Cancer Using Databases.Journal of cancer prevention · 2016Review
- Comment on 'The incidence of leukaemia in women with BRCA1 and BRCA2 mutations: an International Prospective Cohort Study'.British journal of cancer · 2016Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Disparities exist in breast cancer (BC) outcomes between racial and ethnic groups in the United States. Reasons for these disparities are multifactorial including differences in genetics, stage at presentation, access to care, and socioeconomic factors. Less is documented on racial/ethnic differences in subsequent risk of second primary cancers (SPC). The purpose of this study is to evaluate the risk of SPC among different racial/ethnic groups of women with BC. We conducted a retrospective cohort study of 134,868 Non-Hispanic White, 17,484 Black, 18,034 Hispanic, and 19,802 Asian/Pacific Islander (API) women with stages I-III BC in twelve Surveillance, Epidemiology and End Results Program registries between 2001 and 2010. Standardized incidence ratios (SIR), 95 % confidence intervals (CI), and absolute excess risks were calculated by comparing incidence of SPC in the cohort to incidence in the general population for specific cancer sites by race/ethnicity and stratified by index BC characteristics. All women were at increased risks of second primary BC and acute myeloid leukemia (AML), with higher risk among more advanced stage index BC. Black and API women had higher SIRs for AML [4.86 (95 % CI 3.05-7.36) and 5.00 (95 % CI 3.26-7.32)], respectively] which remained elevated among early-stage (I) BC cases. Women with a history of invasive BC have increased risk of SPC, most notable for second primary BC and AML. These risks for secondary cancers differ by race/ethnicity. Studies evaluating possible genetic and biobehavioral mechanisms underlying these differences are warranted. Strategies for BC adjuvant treatment and survivorship care may require further individualization with consideration given to race/ethnicity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.