ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2016
Comparison of the diagnostic accuracies of very low stress-dose with standard-dose myocardial perfusion imaging: Automated quantification of one-day, stress-first SPECT using a CZT camera.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Diagnostic performance of prone-only myocardial perfusion imaging versus coronary angiography in the detection of coronary artery disease: A systematic review and meta-analysis.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Pooled it
- Diagnostic performance of myocardial perfusion imaging with conventional and CZT single-photon emission computed tomography in detecting coronary artery disease: A meta-analysis.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Pooled it
- Pooled it
- Myocardial flow reserve derived from D-SPECT for evaluating non-culprit ischemic lesions in STEMI patients: comparison with quantitative flow ratio.European journal of nuclear medicine and molecular imaging · 2025Article
- Low-dose gated bloodpool SPECT: Is it time to make the shift?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- OptimalJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Effect of reduced photon count levels and choice of normal data on semi-automated image assessment in cardiac SPECT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Quantitative Clinical Nuclear Cardiology, Part 1: Established Applications.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Review
- Quantitative Clinical Nuclear Cardiology, Part 1: Established Applications.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2019Review
- EANM procedural guidelines for myocardial perfusion scintigraphy using cardiac-centered gamma cameras.European journal of hybrid imaging · 2019Article
- The prognostic value of ultra low-dose thallium myocardial perfusion protocol using CZT SPECT.The international journal of cardiovascular imaging · 2019Article
- Advances in imaging instrumentation for nuclear cardiology.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Review
- The effect of CT-based attenuation correction on the automatic perfusion score of myocardial perfusion imaging using a dedicated cardiac solid-state CZT SPECT/CT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- What is the value of motion and thickening in gated myocardial perfusion SPECT?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- The time is now: Dose reduction for myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- PET should not replace routine SPECT MPS for the assessment of patients with known or suspected CAD.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- The radiation dose to overweighted patients undergoing myocardial perfusion SPECT can be significantly reduced: validation of a linear weight-adjusted activity administration protocol.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Review of cardiovascular imaging in the journal of nuclear cardiology in 2016: Part 2 of 2-myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Review
- A world view of nuclear cardiology practices: Think globally, act locally.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Multicenter evaluation of stress-first myocardial perfusion image triage by nuclear technologists and automated quantification.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
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9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies have demonstrated accurate diagnosis of reduced dose myocardial perfusion imaging (MPI) using Cadmium-Zinc-Telluride (CZT) technology. We compared the diagnostic performances of very low stress-dose (<2 mSv) with standard-dose stress-first, quantitative MPI using a CZT camera.
methodsPatients without known coronary artery- disease who underwent a stress-first Tc-99 m sestamibi CZT-MPI and invasive coronary angiography (ICA), and low-risk patients without ICA were included. A stress-rest standard-dose (10/30 mCi) MPI and a low-dose (5/15 mCi) MPI were compared. Normal limits for quantification were developed from 40 (20 males) low-risk patients, and total perfusion deficit (TPD) was derived.
results208 patients who underwent MPI and ICA, and 76 low-risk patients were included. Of these, 128 had a standard-dose MPI and 156 had a low-dose MPI. Stress-doses in low-dose and standard-dose groups were 5.9 ± 1.2 vs 10.2 ± 0.5 mCi (1.7 ± 0.3 vs 3.0 ± 0.1 mSv), respectively, P < 0.001, and stress-rest effective radiation was 6.9 ± 1.1 vs 11.7 ± 0.4 mSv, respectively, P < 0.001. Sensitivity, specificity, and accuracy values in the low-dose and standard-dose groups were 86.1%, 76.6%, and 81.4%; and 90.6%, 78.1%, and 84.4%, respectively, P = ns. Using TPD prone, specificity values were 84.9% and 80.3%, respectively, P = ns.
conclusionOne-day stress-first MPI with 50% radiation reduction and a very low stress-dose (<2 mSv) using CZT technology and quantitative supine and prone analysis provided a high diagnostic value, similar to standard-dose MPI.
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