ArticleOncotarget2015
Influence of age on predictiveness of genetic risk score for prostate cancer in a Chinese hospital-based biopsy cohort.
Article in Oncotarget, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Predictive value of polygenic risk score for prostate cancer incidence and prognosis in the Han Chinese.Scientific reports · 2024Article
- Polygenic risk score for tumor aggressiveness and early-onset prostate cancer in Asians.Scientific reports · 2023Article
- Prediction of clinically significant prostate cancer using polygenic risk models in Asians.Investigative and clinical urology · 2022Article
- Polygenic risk score for genetic evaluation of prostate cancer risk in Asian populations: A narrative review.Investigative and clinical urology · 2021Review
- Genetic risk score to predict biochemical recurrence after radical prostatectomy in prostate cancer: prospective cohort study.Oncotarget · 2017Article
- High mortality risk of prostate cancer patients in Asia and West Africa: A systematic review.Avicenna journal of medicineReview
- Clinical validity and utility of genetic risk scores in prostate cancer.Asian journal of andrologyReview
- A comparison of genetic risk score with family history for estimating prostate cancer risk.Asian journal of andrologyReview
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Authors and funding
8 authors.
Funding
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Abstract
backgroundWe investigated whether age influences the predictiveness of genetic risk score (GRS) for prostate cancer (PCa) in a Chinese hospital-based biopsy cohort.
methodsWe included consecutive patients who underwent prostate biopsies in two tertiary centers between 2012 and 2014. GRS was calculated using 24 PCa-associated genetic variants and its predictiveness was assessed by area under curve (AUC).
resultsOf 1120 men tested, 724 with prostate-specific antigen (PSA) < 20 ng/ml were selected for further analysis. Patients were divided into 3 groups by age cutoffs at 60 and 70 years. GRS significantly predicted PCa for all patients (AUC: 0.561; 95% CI: 0.514-0.609) and was an independent predictor in multivariate analysis for the 60-70 year-olds (AUC: 0.612, 95% CI: 0.541-0.684), but not for patients aged < 60 years or ≥ 70 years. For PCa with Gleason score ≥ 7, GRS discriminative ability was 0.582 (95% CI=0.527-0.637) for all patients, and 0.647 (95% CI: 0.541-0.684) for the 60-70 year-old group.
conclusionGRS significantly increased clinical prediction of PCa and high-grade disease in Chinese men aged 60-70 years, which implies that men in this age group would benefit most from genetic testing.
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