ReviewNutrition reviews2015
Clinical applications of bioactive milk components.
Review in Nutrition reviews, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 108 citations in OpenAlex.
- Major Antioxidants and Methods for Studying Their Total Activity in Milk: A Review.Methods and protocols · 2025Review
- Oncolactation for Patients with Breast Cancer: Executive Summary from the American Society of Breast Surgeons.Annals of surgical oncology · 2025Review
- Guide RNA structure design enables combinatorial CRISPRa programs for biosynthetic profiling.Nature communications · 2024Article
- Milk Bioactive Compounds and Gut Microbiota Modulation: The Role of Whey Proteins and Milk Oligosaccharides.Foods (Basel, Switzerland) · 2024Review
- Effects of dietary PUFA patterns and FADS genotype on breast milk PUFAs in Chinese lactating mothers.Genes & nutrition · 2023Article
- Human milk extracellular vesicles enhance muscle growth and physical performance of immature mice associating with Akt/mTOR/p70s6k signaling pathway.Journal of nanobiotechnology · 2023Article
- Effect of inulin on small extracellular vesicles microRNAs in milk from dairy cows with subclinical mastitis.Journal of animal science · 2023Article
- Lactoferrin Alleviates Lipopolysaccharide-Induced Infantile Intestinal Immune Barrier Damage by Regulating an ELAVL1-Related Signaling Pathway.International journal of molecular sciences · 2022Article
- Review
- Review
- Antiviral properties of whey proteins and their activity against SARS-CoV-2 infection.Journal of functional foods · 2022Review
- The Protective Effects of Lactoferrin on Aflatoxin M1-Induced Compromised Intestinal Integrity.International journal of molecular sciences · 2021Article
- Localization of infection in neonatal rhesus macaques after oral viral challenge.PLoS pathogens · 2021Article
- Human Milk, More Than Simple Nourishment.Children (Basel, Switzerland) · 2021Review
- Anti-Angiogenic Property of Free Human Oligosaccharides.Biomolecules · 2021Review
- Human Milk Microbiota and Oligosaccharides: A Glimpse into Benefits, Diversity, and Correlations.Nutrients · 2021Review
- Breast Milk: A Source of Functional Compounds with Potential Application in Nutrition and Therapy.Nutrients · 2021Review
- A Novel Anti-Infective Peptide BCCY-1 With Immunomodulatory Activities.Frontiers in immunology · 2021Article
- Breast Milk: A Meal Worth Having.Frontiers in nutrition · 2021Review
- More than Nutrition: Therapeutic Potential of Breast Milk-Derived Exosomes in Cancer.International journal of molecular sciences · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Milk represents a unique resource for translational medicine: It contains a rich pool of biologically active molecules with demonstrated clinical benefits. The ongoing characterization of the mechanistic process through which milk components promote development and immunity has revealed numerous milk-derived compounds with potential applications as clinical therapies in infectious and inflammatory disease, cancer, and other conditions. Lactoferrin is an effective antimicrobial and antiviral agent in high-risk patient populations and a potentially potent adjuvant to chemotherapy in lung cancer. Enteric nutrition formulas supplemented with transforming growth factor β, a milk cytokine, have been shown to promote remission in pediatric Crohn's disease. A number of milk glycans, including human milk oligosaccharides, show promise in preclinical studies as antimicrobial and anti-inflammatory agents. While active preclinical investigations of human milk may soon result in large-scale production of human milk molecules, bovine milk components in many instances represent a practical source of bioactive milk compounds for use in clinical trials. This review summarizes current efforts to translate the compounds derived from human and bovine milk into effective clinical therapies. These efforts suggest a common pathway for the translation of milk-derived compounds into clinical applications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.