ArticlePloS one2015
Trends and Determinants of Prescription Drug Use during Pregnancy and Postpartum in British Columbia, 2002-2011: A Population-Based Cohort Study.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06055192 (Prevalence and Burden of Nausea and Vomiting in Pregnant Women in Switzerland), which is not on this map. Cited by 38 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prevalence and Burden of Nausea and Vomiting in Pregnant Women in Switzerland: Survey Purity 2022
Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Estimating the Prevalence of Prescribed Medication Use in Pregnancy with a Systematic Review and Meta-analysis.Drug safety · 2026Pooled it
- Maternal antibiotics exposure during pregnancy and the risk of acute lymphoblastic leukemia in childhood: a systematic review and meta-analysis.European journal of pediatrics · 2022Pooled it
- Association of maternal thyroid function with birthweight: a systematic review and individual-participant data meta-analysis.The lancet. Diabetes & endocrinology · 2020Pooled it
- Doxylamine-pyridoxine for nausea and vomiting of pregnancy randomized placebo controlled trial: Prespecified analyses and reanalysis.PloS one · 2018Trial
- Evaluating the Performance of Traditional Pharmacoepidemiologic and Machine Learning Models to Predict Pregnancies at Risk of Major Congenital Malformations.Birth defects research · 2026Article
- Association of prenatal antidepressant use with internalizing behaviors from kindergarten to adolescence.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Prevalence and Burden of Nausea and Vomiting in Pregnant Women: Final Analysis of the PURITY Survey.Journal of clinical medicine · 2026Article
- Periconceptional antibiotic use and early- to mid-pregnancy psychological distress in a nationwide birth cohort: cross-sectional analysis from the Japan Environment and Children's Study.BMC public health · 2026Article
- Knowledge, Attitude, and Practice of Medication Use During Pregnancy: A Cross-Sectional Study in Western Uganda.Health science reports · 2025Article
- Association Between Antibiotic Exposure During Pregnancy and Postpartum Depressive Symptoms: The Japan Environment and Children's Study.Research in nursing & health · 2025Article
- Maternal Demographic Patterns in Medication use During Pregnancy: A Nationwide Register Study.Basic & clinical pharmacology & toxicology · 2025Article
- Medication use from conception to the first antenatal appointment: agreement between maternal self-report to midwife and prescribing records in Northern Ireland in 2011-2016.International journal of population data science · 2025Article
- Prevalence and association of self-medication practices with personal and educational factors among university employees of Saudi Arabia: A cross-sectional study.Journal of family medicine and primary care · 2024Article
- Use of medication in pregnancy on the rise: Study on 1.4 million Danish pregnancies from 1998 to 2018.Acta obstetricia et gynecologica Scandinavica · 2024Article
- COVID-19 Distribution in Pregnancy, Drug Use Patterns and COVID-19 Medication during the Pandemic in Spain: Data from Real-World Electronic Health Records.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Racial Disparities in Medication Use During Pregnancy: Results from the NISAMI Cohort.Journal of multidisciplinary healthcare · 2024Article
- Patterns of Prescription Medication Use during the First Trimester of Pregnancy in the United States, 1997-2018.Clinical pharmacology and therapeutics · 2023Article
- Self-medication practices among pregnant women in Ethiopia.Journal of pharmaceutical policy and practice · 2023Article
- Potentially harmful medication use and the associated factors among pregnant women visiting antenatal care clinics in Mbarara Regional Referral Hospital, Southwestern Uganda.Journal of clinical and translational research · 2023Article
- Polypharmacy during pregnancy and associated risk factors: a retrospective analysis of 577 medication exposures among 1.5 million pregnancies in the UK, 2000-2019.BMC medicine · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
purposeTo describe trends, patterns, and determinants of prescription drug use during pregnancy and postpartum.
methodsThis is a retrospective, population-based study of all women who gave birth between January 2002 and 31 December 2011 in British Columbia, Canada. Study population consisted of 225,973 women who had 322,219 pregnancies. We examined administrative datasets containing person-specific information on filled prescriptions, hospitalizations, and medical services. Main outcome measures were filled prescriptions during pregnancy and postpartum. We used logistic regressions to examine associations between prescription drug use and maternal characteristics.
resultsApproximately two thirds of women filled a prescription during pregnancy, increasing from 60% in 2002 to 66% in 2011. The proportion of pregnant women using medicines in all three trimesters of pregnancy increased from 20% in 2002 to 27% in 2011. Use of four or more different types of prescription drug during at least one trimester increased from 8.4% in 2002 to 11.7% in 2011. Higher BMI, smoking during pregnancy, age under 25, carrying multiples, and being diagnosed with a chronic condition all significantly increased the odds of prescription drug use during pregnancy.
conclusionsThe observed increase in the number of prescriptions and number of different drugs being dispensed suggests a trend in prescribing practices with potentially important implications for mothers, their neonates, and caregivers. Monitoring of prescribing practices and further research into the safety of most commonly prescribed medications is crucial in better understanding risks and benefits to the fetus and the mother.
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