ArticlePloS one2015
Zearalenone mycotoxin affects immune mediators, MAPK signalling molecules, nuclear receptors and genome-wide gene expression in pig spleen.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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Who cites it
46 citing papers in PubMed, 99 citations in OpenAlex.
- A Preliminary Study on the Effects of Low Doses of Purified Zearalenone in Weaned Female Piglets: A Multi-Organ Toxicity Investigation.Antioxidants (Basel, Switzerland) · 2026Article
- Paternal Zearalenone Exposure Is Associated with Hepatic Dysfunction in F1 Offspring: Insights from Proteomic Analysis.International journal of molecular sciences · 2026Article
- Can antioxidants' supplementation modulate the impact of dietary deoxynivalenol and zearalenone co-contamination on the systemic and mucosal immune response of weaned pigs?Journal of animal science · 2026Article
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- Evaluation of Activity of Pro- and Anti-Inflammatory Mediators and Nitrosative Stress in Liver Tissue of Wild Boars (Toxins · 2025Article
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- Research progress on the prevention and treatment of zearalenone poisoning in animals using natural products.Frontiers in veterinary science · 2025Review
- Dietary administration of Bacillus subtilis improves the health parameters and regulates the gene expression in mice receiving zearalenone-contaminated diet.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Protective and Detoxifying Effects of Resveratrol on Zearalenone-Mediated Toxicity: A Review.International journal of molecular sciences · 2024Review
- Effects of the commensal microbiota on spleen and mesenteric lymph node immune function: investigation in a germ-free piglet model.Frontiers in microbiology · 2024Article
- Current Insights in Fungal Importance-A Comprehensive Review.Microorganisms · 2023Review
- Quercetagetin alleviates zearalenone-induced liver injury in rabbits through Keap1/Nrf2/ARE signaling pathway.Frontiers in pharmacology · 2023Article
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- Exposure to Zearalenone Leads to Metabolic Disruption and Changes in Circulating Adipokines Concentrations in Pigs.Toxins · 2021Article
- Zerumbone Exhibit Protective Effect against Zearalenone Induced Toxicity via Ameliorating Inflammation and Oxidative Stress Induced Apoptosis.Antioxidants (Basel, Switzerland) · 2021Article
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- The Influence of Zearalenone on Selected Hemostatic Parameters in Sexually Immature Gilts.Toxins · 2021Article
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Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The toxicity of zearalenone (ZEA) was evaluated in swine spleen, a key organ for the innate and adaptative immune response. Weaned pigs were fed for 18 days with a control or a ZEA contaminated diet. The effect of ZEA was assessed on wide genome expression, pro- (TNF-α, IL-8, IL-6, IL-1β, IFN-γ) and anti-inflammatory (IL-10, IL-4) cytokines, other molecules involved in inflammatory processes (MMPs/TIMPs), as well as signaling molecules, (p38/JNK1/JNK2-MAPKs) and nuclear receptors (PPARγ/NFkB/AP-1/STAT3/c-JUN). Microarray analysis showed that 46% of total number of differentially expressed genes was involved in cellular signaling pathway, 13% in cytokine network and 10% in the inflammatory response. ZEA increased expression and synthesis of pro- inflammatory (TNF-α, IL-8, IL-6, IL-1β) and had no effect on IFN-γ, IL-4 and IL-10 cytokines in spleen. The inflammatory stimulation might be a consequence of JNK pathway activation rather than of p-38MAPK and NF-kB involvement whose gene and protein expression were suppressed by ZEA action. In summary, our findings indicated the role of ZEA as an immune disruptor at spleen level.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.