Evidence map›Paper›PMID 26011592›Full record

ArticleMetabolites2015

Computational Metabolomics Operations at BioCyc.org.

Peter D Karp, Richard Billington, Timothy A Holland, Anamika Kothari, Markus Krummenacker, Daniel Weaver, Mario Latendresse, Suzanne Paley

Abstract read
In one paragraph

Article in Metabolites, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Article
  3. Co-exposure to polyethylene fiber andApplied and environmental microbiology · 2024
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Metabolomics in Plant Priming Research: The Way Forward?International journal of molecular sciences · 2018
    Review
  10. Current Challenges in Plant Eco-Metabolomics.International journal of molecular sciences · 2018
    Review
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Peter D KarpBioinformatics Research Group, SRI International, 333 Ravenswood Ave AE206, Menlo Park, CA 94025, USA. pkarp@ai.sri.com.
Richard BillingtonBioinformatics Research Group, SRI International, 333 Ravenswood Ave AE206, Menlo Park, CA 94025, USA. billingt@ai.sri.com.
Timothy A HollandBioinformatics Research Group, SRI International, 333 Ravenswood Ave AE206, Menlo Park, CA 94025, USA. timothy.holland@sri.com.
Anamika KothariBioinformatics Research Group, SRI International, 333 Ravenswood Ave AE206, Menlo Park, CA 94025, USA. kothari@ai.sri.com.
Markus KrummenackerBioinformatics Research Group, SRI International, 333 Ravenswood Ave AE206, Menlo Park, CA 94025, USA. kr@ai.sri.com.
Daniel WeaverBioinformatics Research Group, SRI International, 333 Ravenswood Ave AE206, Menlo Park, CA 94025, USA. weaver@ai.sri.com.
Mario LatendresseBioinformatics Research Group, SRI International, 333 Ravenswood Ave AE206, Menlo Park, CA 94025, USA. latendre@ai.sri.com.
Suzanne PaleyBioinformatics Research Group, SRI International, 333 Ravenswood Ave AE206, Menlo Park, CA 94025, USA. paley@ai.sri.com.

Funding

The MetaCyc & BioCyc Pathway/Genome Databases (SRI Proposal ECU 14-630)R01GM080746 · NIGMS · SRI INTERNATIONAL · PI CASPI, RON, KARP, PETER D · 2007 to 2021
$15.6M
Robust Software Components for Model Organism DatabasesR01GM075742 · NIGMS · SRI INTERNATIONAL · PI KARP, PETER D · 2005 to 2019
$12.0M
NIGMS NIH HHS R01 GM075742NIGMS NIH HHS R01 GM080746
6 · The paper itself

Abstract

BioCyc.org is a genome and metabolic pathway web portal covering 5500 organisms, including Homo sapiens, Arabidopsis thaliana, Saccharomyces cerevisiae and Escherichia coli. These organism-specific databases have undergone variable degrees of curation. The EcoCyc (Escherichia coli Encyclopedia) database is the most highly curated; its contents have been derived from 27,000 publications. The MetaCyc (Metabolic Encyclopedia) database within BioCyc is a "universal" metabolic database that describes pathways, reactions, enzymes and metabolites from all domains of life. Metabolic pathways provide an organizing framework for analyzing metabolomics data, and the BioCyc website provides computational operations for metabolomics data that include metabolite search and translation of metabolite identifiers across multiple metabolite databases. The site allows researchers to store and manipulate metabolite lists using a facility called SmartTables, which supports metabolite enrichment analysis. That analysis operation identifies metabolite sets that are statistically over-represented for the substrates of specific metabolic pathways. BioCyc also enables visualization of metabolomics data on individual pathway diagrams and on the organism-specific metabolic map diagrams that are available for every BioCyc organism. Most of these operations are available both interactively and as programmatic web services.

Indexed as

metabolic databasemetabolic pathwaysmetabolomics data analysis

Identifiers

PMID26011592
PMCPMC4495374

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.