Evidence map›Paper›PMID 26011549›Full record

Trial reportJournal of managed care & specialty pharmacy2015

Patient-reported medication adherence barriers among patients with cardiovascular risk factors.

Leah L Zullig, Karen M Stechuchak, Karen M Goldstein, Maren K Olsen, Felicia M McCant, Susanne Danus, Matthew J Crowley, Eugene Z Oddone, Hayden B Bosworth

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of managed care & specialty pharmacy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01142908 (Cardiovascular Intervention Improvement Telemedicine Study), which is not on this map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01142908 nacompletednot on this map

Cardiovascular Intervention Improvement Telemedicine Study

TypeinterventionalSponsorVA Office of Research and DevelopmentRan2011 to 2015Enrolled428ConditionsCardiovascular Disease, Hypertension, Diabetes, HyperlipidemiaArmsPharmacist CVD
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Perceived appropriateness of medication adherence incentives.Journal of managed care & specialty pharmacy · 2021
    Article
  7. Article
  8. Article
  9. Review
  10. Enrollment and Retention of Men and Women in Health Services Research and Development Trials.Women's health issues : official publication of the Jacobs Institute of Women's Health · 2019
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Raising the Bar in Renal Sympathetic Denervation Research and Reporting.Journal of clinical hypertension (Greenwich, Conn.) · 2016
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Leah L ZulligDuke University Medical Center, 411 W. Chapel Hill St., Ste. 600, Durham, NC 27701. hayden.bosworth@duke.edu.
Karen M Stechuchak
Karen M Goldstein
Maren K Olsen
Felicia M McCant
Susanne Danus
Matthew J Crowley
Eugene Z Oddone
Hayden B Bosworth

Funding

HSRD VA CDA 13-025HSRD VA CDA 13-261HSRD VA IK2 HX001345
6 · The paper itself

Abstract

backgroundMany patients experience barriers that make it difficult to take cardiovascular disease (CVD)-related medications as prescribed. The Cardiovascular Intervention Improvement Telemedicine Study (CITIES) was a tailored behavioral pharmacist-administered and telephone-based intervention for reducing CVD risk.

objectivesTo (a) describe patient-reported barriers to taking their medication as prescribed and (b) evaluate patient-level characteristics associated with reporting medication barriers.

methodsWe recruited patients receiving care at primary care clinics affiliated with Durham Veterans Affairs Medical Center. Eligible patients were diagnosed with hypertension and/or hyperlipidemia that were poorly controlled (blood pressure of > 150/100 mmHg and/or low-density lipoprotein value > 130 mg/dL). At the time of enrollment, patients completed an interview with 7 questions derived from a validated medication barriers measure. Patient characteristics and individual medication treatment barriers are described. Multivariable linear regression was used to examine the association between a medication barrier score and patient characteristics.

resultsMost patients (n = 428) were married or living with their partners (57%) and were men (85%) who were diagnosed with hypertension and hyperlipidemia (64%). The most commonly reported barriers were having too much medication to take (31%) and forgetting whether medication was taken at a particular time (24%). In adjusted analysis, those who were not employed (1.32, 95% CI = 0.50-2.14) or did not have someone to help with tasks, if needed (1.66, 95% CI = 0.42-2.89), reported higher medication barrier scores. Compared with those diagnosed with hypertension and hyperlipidemia, those with only hypertension (0.91, 95% CI = 0.04-1.79) reported higher medication barrier scores.

conclusionsBarriers to medication adherence are common. Evaluating and addressing barriers may increase medication adherence.

Indexed as

Drug MonitoringAgedCardiovascular DiseasesFemaleHospitals, VeteransHumansHyperlipidemiasHypertensionLinear ModelsMaleMiddle AgedPharmacistsPharmacy Service, HospitalPrimary Health CareRisk FactorsTelephone

Identifiers

PMID26011549
PMCPMC10401992

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.