Evidence map›Paper›PMID 26011418›Full record

ArticlePloS one2015

Age-related differences in the accuracy of web query-based predictions of influenza-like illness.

Alexander Domnich, Donatella Panatto, Alessio Signori, Piero Luigi Lai, Roberto Gasparini, Daniela Amicizia

Abstract read
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alexander DomnichDepartment of Health Sciences, University of Genoa, Genoa, Italy.
Donatella PanattoDepartment of Health Sciences, University of Genoa, Genoa, Italy; Inter-University Centre of Research on Influenza and other Transmissible Infections (CIRI-IT), Genoa, Italy.
Alessio SignoriDepartment of Health Sciences, University of Genoa, Genoa, Italy.
Piero Luigi LaiDepartment of Health Sciences, University of Genoa, Genoa, Italy; Inter-University Centre of Research on Influenza and other Transmissible Infections (CIRI-IT), Genoa, Italy.
Roberto GaspariniDepartment of Health Sciences, University of Genoa, Genoa, Italy; Inter-University Centre of Research on Influenza and other Transmissible Infections (CIRI-IT), Genoa, Italy.
Daniela AmiciziaDepartment of Health Sciences, University of Genoa, Genoa, Italy; Inter-University Centre of Research on Influenza and other Transmissible Infections (CIRI-IT), Genoa, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWeb queries are now widely used for modeling, nowcasting and forecasting influenza-like illness (ILI). However, given that ILI attack rates vary significantly across ages, in terms of both magnitude and timing, little is known about whether the association between ILI morbidity and ILI-related queries is comparable across different age-groups. The present study aimed to investigate features of the association between ILI morbidity and ILI-related query volume from the perspective of age.

methodsSince Google Flu Trends is unavailable in Italy, Google Trends was used to identify entry terms that correlated highly with official ILI surveillance data. All-age and age-class-specific modeling was performed by means of linear models with generalized least-square estimation. Hold-out validation was used to quantify prediction accuracy. For purposes of comparison, predictions generated by exponential smoothing were computed.

resultsFive search terms showed high correlation coefficients of > .6. In comparison with exponential smoothing, the all-age query-based model correctly predicted the peak time and yielded a higher correlation coefficient with observed ILI morbidity (.978 vs. .929). However, query-based prediction of ILI morbidity was associated with a greater error. Age-class-specific query-based models varied significantly in terms of prediction accuracy. In the 0-4 and 25-44-year age-groups, these did well and outperformed exponential smoothing predictions; in the 15-24 and ≥ 65-year age-classes, however, the query-based models were inaccurate and highly overestimated peak height. In all but one age-class, peak timing predicted by the query-based models coincided with observed timing.

conclusionsThe accuracy of web query-based models in predicting ILI morbidity rates could differ among ages. Greater age-specific detail may be useful in flu query-based studies in order to account for age-specific features of the epidemiology of ILI.

Indexed as

InternetSearch EngineAdolescentAdultAgedAge FactorsChildChild, PreschoolHumansInfantInfant, NewbornInfluenza, HumanItalyMiddle AgedMorbidityReproducibility of Results

Identifiers

PMID26011418
PMCPMC4444192

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.