ArticlePloS one2015
A Virulence Essential CRN Effector of Phytophthora capsici Suppresses Host Defense and Induces Cell Death in Plant Nucleus.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Molecular Interactions Between Soil-Borne Oomycetes and Plants: Infection Mechanisms, Host Resistance, and Implications for Sustainable Agriculture.Plants (Basel, Switzerland) · 2026Review
- Identification of Phytophthora cinnamomi CRN effectors and their roles in manipulating cell death during Persea americana infection.BMC genomics · 2024Article
- PcLRR-RK3, an LRR receptor kinase is required for growth andMycology · 2024Article
- Lasiodiplodia theobromae protein LtScp1 contributes to fungal virulence and protects fungal mycelia against hydrolysis by grapevine chitinase.Environmental microbiology · 2022Article
- Virulence strategies of an insect herbivore and oomycete plant pathogen converge on host E3 SUMO ligase SIZ1.The New phytologist · 2022Article
- Unraveling Plant Cell Death duringMicroorganisms · 2022Review
- A novel effector, CsSp1, from Bipolaris sorokiniana, is essential for colonization in wheat and is also involved in triggering host immunity.Molecular plant pathology · 2022Article
- Differing Responses toFrontiers in plant science · 2022Article
- High-Quality Reference Genome Sequence for the Oomycete Vegetable Pathogen Phytophthora capsici Strain LT1534.Microbiology resource announcements · 2021Article
- Agroinfiltration for transient gene expression and characterisation of fungal pathogen effectors in cool-season grain legume hosts.Plant cell reports · 2021Article
- Organize, Don't Agonize: Strategic Success ofMicroorganisms · 2020Review
- Effectors of Phytophthora pathogens are powerful weapons for manipulating host immunity.Planta · 2019Review
- The Nuclear-Localized RxLR Effector PvAvh74 FromFrontiers in microbiology · 2019Article
- Arms race: diverse effector proteins with conserved motifs.Plant signaling & behavior · 2019Article
- Random mutagenesis screen shows that Phytophthora capsici CRN83_152-mediated cell death is not required for its virulence function(s).Molecular plant pathology · 2018Article
- Phytophthora cinnamomi.Molecular plant pathology · 2018Article
- RiCRN1, a Crinkler Effector From the Arbuscular Mycorrhizal FungusFrontiers in microbiology · 2018Article
- Genome sequence of Plasmopara viticola and insight into the pathogenic mechanism.Scientific reports · 2017Article
- A candidate RxLR effector from Plasmopara viticola can elicit immune responses in Nicotiana benthamiana.BMC plant biology · 2017Article
- PAMPs, PRRs, effectors and R-genes associated with citrus-pathogen interactions.Annals of botany · 2017Review
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phytophthora capsici is a soil-borne plant pathogen with a wide range of hosts. The pathogen secretes a large array of effectors during infection of host plants, including Crinkler (CRN) effectors. However, it remains largely unknown on the roles of these effectors in virulence especially in P. capsici. In this study, we identified a cell death-inducing CRN effector PcCRN4 using agroinfiltration approach. Transient expression of PcCRN4 gene induced cell death in N. benthamiana, N. tabacum and Solanum lycopersicum. Overexpression of the gene in N. benthamiana enhanced susceptibility to P. capsici. Subcellular localization results showed that PcCRN4 localized to the plant nucleus, and the localization was required for both of its cell death-inducing activity and virulent function. Silencing PcCRN4 gene in P. capsici significantly reduced pathogen virulence. The expression of the pathogenesis-related gene PR1b in N. benthamiana was significantly induced when plants were inoculated with PcCRN4-silenced P. capsici transformant compared to the wilt-type. Callose deposits were also abundant at sites inoculated with PcCRN4-silenced transformant, indicating that silencing of PcCRN4 in P. capsici reduced the ability of the pathogen to suppress plant defenses. Transcriptions of cell death-related genes were affected when PcCRN4-silenced line were inoculated on Arabidopsis thaliana, suggesting that PcCRN4 may induce cell death by manipulating cell death-related genes. Overall, our results demonstrate that PcCRN4 is a virulence essential effector and it needs target to the plant nucleus to suppress plant immune responses.
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