ArticlePloS one2015
A detailed family history of myocardial infarction and risk of myocardial infarction--a nationwide cohort study.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- Occluded Coronary Artery among Non-ST Elevation Myocardial Infarction Patients in Department of Cardiology of a Tertiary Care Centre: A Descriptive Cross-sectional Study.JNMA; journal of the Nepal Medical Association · 2023Trial
- Are associations of childhood body mass index trajectories with early-onset coronary heart disease modified by parental history of cardiovascular disease?International journal of obesity (2005) · 2026Article
- Inherited risk of coronary artery disease: redefining care with imaging and genetics.Nature reviews. Cardiology · 2026Review
- Validation of self-reported family history of myocardial infarction using nationwide health care data.European journal of epidemiology · 2026Article
- Impact of Genetic Risk Factors on Coronary Heart Disease Risk Across the Age Spectrum in Three Major Race/Ethnicity Groups in the United States.medRxiv : the preprint server for health sciences · 2025Article
- Risk factors of acute coronary syndrome among patients admitted to cardiac care units at governmental hospitals in the Gaza Strip: Case- control study.International journal of cardiology. Cardiovascular risk and prevention · 2025Article
- IntronicInternational journal of molecular sciences · 2025Article
- Family history of cardiovascular disease and death in patients with out-of-hospital cardiac arrest.Resuscitation plus · 2025Article
- Coronary risk factor profiles according to different age categories in premature coronary artery disease patients who have undergone percutaneous coronary intervention.Scientific reports · 2024Article
- Cardiovascular Family History Increases the Risk of Disease Recurrence After a First Myocardial Infarction.Journal of the American Heart Association · 2021Article
- The Role of Family Health History in Predicting Midlife Chronic Disease Outcomes.American journal of preventive medicine · 2021Article
- Polymorphisms of LPA gene, rs1801693 and rs7765781, are not associated with premature myocardial infarction in the Iranian population.ARYA atherosclerosis · 2021Article
- Coronary risk reduction intervention for siblings and offspring of patients with premature coronary heart disease: the CRISO study protocol for a randomised controlled pilot study.Pilot and feasibility studies · 2021Article
- Mechanisms underlying familial aggregation of exceptional health and survival: A three-generation cohort study.Aging cell · 2020Article
- Younger age of patients with myocardial infarction is associated with a higher number of relatives with a history of premature atherosclerosis.BMC cardiovascular disorders · 2020Article
- Article
- The design and rationale of SAVE BC: The Study to Avoid CardioVascular Events in British Columbia.Clinical cardiology · 2018Observational
- Risk for hypertension crosses generations in the community: a multi-generational cohort study.European heart journal · 2017Article
- Beyond Coronary Calcification, Family History, and C-Reactive Protein: Cholesterol Efflux Capacity and Cardiovascular Risk Prediction.Journal of the American College of Cardiology · 2016Article
- Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFamily history of myocardial infarction (MI) is an independent risk factor for MI. Several genetic variants are associated with increased risk of MI and family history of MI in a first-degree relative doubles MI risk. However, although family history of MI is not a simple dichotomous risk factor, the impact of specific, detailed family histories has not received much attention, despite its high clinical relevance. We examined risk of MI by MIs in first- and second-degree relatives and by number and age of affected relatives. METHODS AND
findingsUsing Danish national registers, we established a nationwide cohort of persons born between 1930 and 1992 with identifiable first- or second-degree relatives. Incident MIs in both cohort members and relatives aged ≥20 years were identified. We calculated incidence rate ratios (IRRs) for MI by family history of MI, by Poisson regression. In 4.4 million persons followed for 104 million person-years, we identified 128,384 incident MIs. IRRs with 95% confidence intervals [CIs] for MI by history of MI in 1, 2 or ≥3 first-degree relatives were 1.46 (1.42-1.49), 2.38 (2.22-2.56) and 3.58 (2.66-4.81), respectively. Corresponding estimates for second-degree relatives were 1.17 (1.05-1.30), 1.87 (1.46-2.38) and 2.18 (1.09-4.36). A history of MI in combinations of first- and second-degree relatives increased risks 1.8- to 7-fold in middle-aged persons (36 to 55 years). Estimates were robust to adjustment for diabetes, hypertension, dyslipidemia and use of cardiovascular medications.
conclusionA detailed family history, particularly number of affected first- and second-degree relatives, contributes meaningfully to risk assessment, especially in middle-aged persons. Future studies should test for potential improvement of risk algorithm prediction using detailed family histories.
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