ArticleAutism research : official journal of the International Society for Autism Research2015
Patterns of Risk for Multiple Co-Occurring Medical Conditions Replicate Across Distinct Cohorts of Children with Autism Spectrum Disorder.
Article in Autism research : official journal of the International Society for Autism Research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 3 of them syntheses that pooled it.
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Who cites it
71 citing papers in PubMed, 3 syntheses or guidelines pooled it, 127 citations in OpenAlex.
- Population-Based Psychiatric Comorbidity in Children and Adolescents With Autism Spectrum Disorder: A Meta-Analysis.Frontiers in psychiatry · 2022Pooled it
- Prevalence of Autism Spectrum Disorder and Co-morbidities in Children and Adolescents: A Systematic Literature Review.Frontiers in psychiatry · 2021Pooled it
- Medical comorbidities in children and adolescents with autism spectrum disorders and attention deficit hyperactivity disorders: a systematic review.European child & adolescent psychiatry · 2017Pooled it
- From Genetic Determinism to Epigenetic Regulation: Paradigm Shifts in the Understanding of Neurodevelopmental Disorders.Current issues in molecular biology · 2026Review
- Medical comorbidities in autistic children: prevalence, sex-specific clustering, and network patterns at diagnosis in a Chilean cohort.European journal of pediatrics · 2026Article
- Transdiagnostic clinical correlates for behaviors of concern in pediatric neurodevelopmental disorders: a retrospective chart review and machine learning analysis.Frontiers in psychiatry · 2026Article
- Parallel paths: A narrative review exploring autism and its co-occurring conditions.World journal of clinical pediatrics · 2025Review
- A longitudinal evaluation of gastrointestinal symptoms in children with autism spectrum disorder.Autism : the international journal of research and practice · 2025Article
- Novel Insights into Somatic Comorbidities in Children and Adolescents Across Psychiatric Diagnoses: An Explorative Study.Child psychiatry and human development · 2025Article
- Changes in Autism Traits from Early Childhood to Adolescence in the Study to Explore Early Development.medRxiv : the preprint server for health sciences · 2025Article
- Article
- EEG Abnormalities and Phenotypic Correlates in Preschoolers with Autism Spectrum Disorder: A Single-Center Study.Journal of clinical medicine · 2025Article
- Exploring the potential association between dietary factors and autism spectrum disorder: a Mendelian randomization analysis and retrospective study.Frontiers in nutrition · 2025Article
- An Overview of Pharmacotherapy in the Management of Children with Autism Spectrum Disorder at a Public Hospital in KwaZulu-Natal.Child psychiatry and human development · 2024Article
- A conditional multi-label model to improve prediction of a rare outcome: An illustration predicting autism diagnosis.Journal of biomedical informatics · 2024Article
- Autistic Traits and Somatic Symptom Disorders: What Is the Link?Brain sciences · 2024Review
- Drug-refractory irritability and related factors in autistic children.International journal of developmental disabilities · 2024Article
- Autism spectrum disorder: Comorbidity and demographics in a clinical sample.International journal of developmental disabilities · 2024Article
- Assessment of autonomic symptom scales in patients with neurodevelopmental diagnoses using electronic health record data.Research in autism spectrum disorders · 2023Article
- Parenting stress and autistic children's emotional problems relate to family-school partnerships and parent mental health.School psychology (Washington, D.C.) · 2023Article
11 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Children with autism spectrum disorder (ASD) may present with multiple medical conditions in addition to ASD symptoms. This study investigated whether there are predictive patterns of medical conditions that co-occur with ASD, which could inform medical evaluation and treatment in ASD, as well as potentially identify etiologically meaningful subgroups. Medical history data were queried in the multiplex family Autism Genetic Resource Exchange (AGRE). Fourteen medical conditions were analyzed. Replication in the Simons Simplex Collection (SSC) was attempted using available medical condition data on gastrointestinal disturbances (GID), sleep problems, allergy and epilepsy. In the AGRE cohort, no discrete clusters emerged among 14 medical conditions. GID and seizures were enriched in unaffected family members, and together with sleep problems, were represented in both AGRE and SSC. Further analysis of these medical conditions identified predictive co-occurring patterns in both samples. For a child with ASD, the presence of GID predicts sleep problems and vice versa, with an approximately 2-fold odds ratio in each direction. These risk patterns were replicated in the SSC sample, and in addition, there was increased risk for seizures and sleep problems to co-occur with GID. In these cohorts, seizure alone was not predictive of the other conditions co-occurring, but behavioral impairments were more severe as the number of co-occurring medical symptoms increased. These findings indicate that interdisciplinary clinical care for children with ASD will benefit from evaluation for specific patterns of medical conditions in the affected child and their family members.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.