ArticleJournal of neurochemistry2015
Optogenetic versus electrical stimulation of dopamine terminals in the nucleus accumbens reveals local modulation of presynaptic release.
Article in Journal of neurochemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 66 citations in OpenAlex.
- Article
- Irregular optogenetic stimulation waveforms can induce naturalistic patterns of hippocampal spectral activity.Journal of neural engineering · 2024Article
- Article
- Wireless, Battery-Free Implants for Electrochemical Catecholamine Sensing and Optogenetic Stimulation.ACS nano · 2023Article
- High frequency deep brain stimulation can mitigate the acute effects of cocaine administration on tonic dopamine levels in the rat nucleus accumbens.Frontiers in neuroscience · 2023Article
- Estrogen receptors observed at extranuclear neuronal sites and in glia in the nucleus accumbens core and shell of the female rat: Evidence for localization to catecholaminergic and GABAergic neurons.The Journal of comparative neurology · 2022Article
- Transhemispheric cortex remodeling promotes forelimb recovery after spinal cord injury.JCI insight · 2022Article
- Diurnal rhythms in cholinergic modulation of rapid dopamine signals and associative learning in the striatum.Cell reports · 2022Article
- Distinct limbic dopamine regulation across olfactory-tubercle subregions through integration of in vivo fast-scan cyclic voltammetry and optogenetics.Journal of neurochemistry · 2022Article
- Dopamine Release in Nucleus Accumbens Is under Tonic Inhibition by Adenosine AThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Striatal low-threshold spiking interneurons locally gate dopamine.Current biology : CB · 2021Article
- Axonal Modulation of Striatal Dopamine Release by Local γ-Aminobutyric Acid (GABA) Signalling.Cells · 2021Review
- Insulin restores the neurochemical effects of nicotine in the mesolimbic pathway of diabetic rats.Journal of neurochemistry · 2021Article
- Organic cation transporter 3 and the dopamine transporter differentially regulate catecholamine uptake in the basolateral amygdala and nucleus accumbens.The European journal of neuroscience · 2020Article
- Prefrontal Cortex-Driven Dopamine Signals in the Striatum Show Unique Spatial and Pharmacological Properties.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Different adaptations of dopamine release in Nucleus Accumbens shell and core of individual alcohol drinking groups of mice.Neuropharmacology · 2020Article
- Article
- New era of optogenetics: from the central to peripheral nervous system.Critical reviews in biochemistry and molecular biology · 2020Review
- Optogenetic analysis of respiratory neuronal networks in the ventral medulla of neonatal rats producing channelrhodopsin in Phox2b-positive cells.Pflugers Archiv : European journal of physiology · 2019Article
- Heterosynaptic GABAThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The nucleus accumbens is highly heterogeneous, integrating regionally distinct afferent projections and accumbal interneurons, resulting in diverse local microenvironments. Dopamine (DA) neuron terminals similarly express a heterogeneous collection of terminal receptors that modulate DA signaling. Cyclic voltammetry is often used to probe DA terminal dynamics in brain slice preparations; however, this method traditionally requires electrical stimulation to induce DA release. Electrical stimulation excites all of the neuronal processes in the stimulation field, potentially introducing simultaneous, multi-synaptic modulation of DA terminal release. We used optogenetics to selectively stimulate DA terminals and used voltammetry to compare DA responses from electrical and optical stimulation of the same area of tissue around a recording electrode. We found that with multiple pulse stimulation trains, optically stimulated DA release increasingly exceeded that of electrical stimulation. Furthermore, electrical stimulation produced inhibition of DA release across longer duration stimulations. The GABAB antagonist, CGP 55845, increased electrically stimulated DA release significantly more than light stimulated release. The nicotinic acetylcholine receptor antagonist, dihydro-β-erythroidine hydrobromide, inhibited single pulse electrically stimulated DA release while having no effect on optically stimulated DA release. Our results demonstrate that electrical stimulation introduces local multi-synaptic modulation of DA release that is absent with optogenetically targeted stimulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.