Evidence map›Paper›PMID 26011043›Full record

ArticlePloS one2015

Clinical characteristics and molecular epidemiology of noroviruses in outpatient children with acute gastroenteritis in Huzhou of China.

Weihua Zou, Dawei Cui, Xiang Wang, Huihui Guo, Xing Yao, Miao Jin, Qiuling Huang, Min Gao, Xiaohong Wen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. [Molecular epidemiology of norovirus in children with acute gastroenteritis in Tianjin, China].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2019
    Article
  7. Article
  8. Norovirus prevalence and estimated viral load in symptomatic and asymptomatic children from rural communities of Vhembe district, South Africa.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2016
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Weihua ZouDepartment of Clinical Laboratory, Huzhou Central Hospital, Huzhou 313000, China.
Dawei CuiCenter of Clinical Laboratory, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China.
Xiang WangCenter of Clinical Laboratory, The First People's Hospital of Huzhou, Huzhou Teachers College, Huzhou, 313000, China.
Huihui GuoCenter of Clinical Laboratory, The First People's Hospital of Huzhou, Huzhou Teachers College, Huzhou, 313000, China.
Xing YaoDepartment of Clinical Laboratory, Huzhou Central Hospital, Huzhou 313000, China.
Miao JinNational Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.
Qiuling HuangDepartment of Clinical Laboratory, Huzhou Central Hospital, Huzhou 313000, China.
Min GaoDepartment of Clinical Laboratory, Huzhou Central Hospital, Huzhou 313000, China.
Xiaohong WenCenter of Clinical Laboratory, The First People's Hospital of Huzhou, Huzhou Teachers College, Huzhou, 313000, China.
Huzhou Central Hospital · CNHuzhou University · CNNational Institute for Viral Disease Control and Prevention · CNThird People's Hospital of Huzhou · CNZhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNoroviruses (NoVs) are considered major causative pathogens associated with the morbidity and mortality of young children with acute gastroenteritis. However, few studies have examined NoVs causing acute diarrhea among outpatient children worldwide. This study was conducted to investigate the clinical features and molecular epidemiology of NoVs in outpatient children with acute gastroenteritis in Huzhou, China, between April 2013 and April 2014.

methodsStool specimens from 1346 outpatient children enrolled (under 5 years of age) with acute gastroenteritis were examined for NoVs by multiplex RT-PCR, and sequences of the partial capsids of NoVs were analyzed phylogenetically, while the relevant clinical data were analyzed statistically.

resultsOf 1346 specimens, 383 (28.5%, 383/1346) were positive for NoVs. The proportion of GII genotypes (26.9%) was significantly higher than that of GI genotypes (1.6%). The GII.4 genotype was the most prevalent of GII genotypes and was clustered into GII.4/Sydney (37.8%) and GII.4/2006b (62.2%), whereas GI strains were clustered into GI.1. Additionally, the younger children (12 to <24 months of age) were more susceptible to NoVs than children in other age groups, and the highest percentage of NoV infections occurred in April 2013. The diarrheal frequency (times/d) and WBC counts of the infected outpatient group with NoVs were significantly higher than were those of the uninfected outpatient group.

conclusionNoVs were confirmed to be the major viral agents responsible for acute gastroenteritis in outpatient children in Huzhou, China, and GII.4/Sydney and GII.4/2006b variants were identified as the predominant strains in this study.

Indexed as

Caliciviridae InfectionsChild, PreschoolChinaFecesFemaleGastroenteritisGenetic VariationHumansInfantMaleMolecular EpidemiologyNorovirusOutpatientsPrevalenceRNA, ViralRNA, Viral

Identifiers

PMID26011043
PMCPMC4444205
OpenAlexW1491985870

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.