Evidence map›Paper›PMID 26010615›Full record

ArticlePloS one2015

Depression in persons with diabetes by age and antidiabetic treatment: a cross-sectional analysis with data from the Hordaland Health Study.

Line I Berge, Trond Riise, Grethe S Tell, Marjolein M Iversen, Truls Østbye, Anders Lund, Ann Kristin Knudsen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Age matters: association between age and depression severity at the time of OSA diagnosis and PAP adherence in adult patients.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024
    Observational
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Severe Depressive Episode with Psychotic Symptoms and Type 2 Diabetes: A 2010-2017 Longitudinal Study.Medical science monitor : international medical journal of experimental and clinical research · 2019
    Article
  12. Review
  13. Article
  14. Article
  15. Diabetes and depression in Lebanon and association with glycemic control: a cross-sectional study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2018
    Article
  16. Review
  17. Comorbidity of depression and diabetes: an application of biopsychosocial model.International journal of mental health systems · 2016
    Article
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Line I BergeDepartment of Global Public Health and Primary Care, University of Bergen, Bergen, Norway; Department of Clinical Medicine 1, Section of Psychiatry, University of Bergen, Bergen, Norway; Mood Net Research Group, Haukeland University Hospital/University of Bergen, Bergen, Norway.
Trond RiiseDepartment of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
Grethe S TellDepartment of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
Marjolein M IversenCentre for Evidence-Based Practice, Bergen University College, Bergen, Norway; Section of Endocrinology, Department of Medicine, Stavanger University Hospital, Stavanger, Norway.
Truls ØstbyeDepartment of Global Public Health and Primary Care, University of Bergen, Bergen, Norway; Global Health Institute, Duke University, North Carolina, United States of America.
Anders LundDepartment of Clinical Medicine 1, Section of Psychiatry, University of Bergen, Bergen, Norway; Mood Net Research Group, Haukeland University Hospital/University of Bergen, Bergen, Norway.
Ann Kristin KnudsenDepartment of Global Public Health and Primary Care, University of Bergen, Bergen, Norway; Department of Health Registries, Norwegian Institute of Public Health, Bergen, Norway.
University of Bergen · NONorwegian Institute of Public Health · NOStavanger University Hospital · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPersons with diabetes have increased risk of depression, however, studies addressing whether the risk varies by age and type of antidiabetic treatment have yielded conflicting results. The aim of this study was to investigate if the association between diabetes and depression varied by type of antidiabetic treatment in a large community based sample of middle-aged (40-47 years) and older adults (70-72 years).

methodsData from 21845 participants in the Hordaland Health Study (HUSK) were analyzed in a cross-sectional design. Diabetes was assessed by self-report and classified as un-medicated, treated by oral antidiabetic agents or by insulin. Depression was defined as a score ≥ 8 on the depression subscale of the Hospital Anxiety and Depression Scale and/or self-reported use of antidepressant agents. Associations between diabetes and depression were estimated using logistic regression.

resultsPersons in their forties with diabetes had a doubled prevalence of depression (OR: 1.96 (95% C.I.: 1.35, 2.83)) compared to persons without diabetes, while a lower and non-significant association was found among persons in their seventies. Persons in their forties with orally treated diabetes had about three times higher prevalence of depression (OR: 2.92 (95% C.I.: 1.48, 5.77)) after adjustment for gender, BMI, physical activity, alcohol consumption and education, compared to non-diabetic persons in the same age-group. No association between depression and insulin or un-medicated diabetes was found.

conclusionsClinicians should be aware that persons in their forties with orally treated diabetes are at a marked increased risk of depression.

Indexed as

AdultAgedAnxietyAnxiety DisordersCross-Sectional StudiesDepressionDepressive DisorderDiabetes Mellitus, Type 2FemaleHumansHypoglycemic AgentsInsulinMaleMiddle AgedPrevalencePsychiatric Status Rating ScalesHypoglycemic AgentsInsulin

Identifiers

PMID26010615
PMCPMC4444007
OpenAlexW2395634581

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.