ArticlePloS one2015
Up-Regulation of MiR-300 Promotes Proliferation and Invasion of Osteosarcoma by Targeting BRD7.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Prognostic role of 14q32.31 miRNA cluster in various carcinomas: a systematic review and meta-analysis.Clinical & experimental metastasis · 2020Pooled it
- Retraction: By downregulating TIAM1 expression, microRNA-329 suppresses gastric cancer invasion and growth.Oncotarget · 2026Article
- Retraction: MicroRNA-595 sensitizes ovarian cancer cells to cisplatin by targeting ABCB1.Oncotarget · 2026Article
- Circ_0000419 acts as a tumor suppressor in gastric cancer development via regulating miR-300/RGMB axis.International journal of clinical oncology · 2023Article
- Retraction: miR-203 Acts as a Tumor Suppressor Gene in Osteosarcoma by Regulating RAB22A.PloS one · 2023Article
- Article
- Mxi1 participates in the progression of lung cancer via the microRNA-300/KLF9/GADD34 Axis.Cell death & disease · 2022Article
- Retraction: MicroRNA-503 Acts as a Tumor Suppressor in Osteosarcoma by Targeting L1CAM.PloS one · 2022Article
- Retraction: MicroRNA-217 Regulates WASF3 Expression and Suppresses Tumor Growth and Metastasis in Osteosarcoma.PloS one · 2022Article
- Retraction: MicroRNA-33b Suppresses Migration and Invasion by Targeting c-Myc in Osteosarcoma Cells.PloS one · 2022Article
- Retraction: MicroRNA-153 Inhibits Osteosarcoma Cells Proliferation and Invasion by Targeting TGF-β2.PloS one · 2022Article
- Retraction: MicroRNA-137 Upregulation Increases Bladder Cancer Cell Proliferation and Invasion by Targeting PAQR3.PloS one · 2022Article
- Retraction: Up-Regulation of MiR-300 Promotes Proliferation and Invasion of Osteosarcoma by Targeting BRD7.PloS one · 2022Article
- Retraction: MicroRNA-410 Suppresses Migration and Invasion by Targeting MDM2 in Gastric Cancer.PloS one · 2022Article
- Emerging Roles of BRD7 in Pathophysiology.International journal of molecular sciences · 2020Review
- BRD7 suppresses invasion and metastasis in breast cancer by negatively regulating YB1-induced epithelial-mesenchymal transition.Journal of experimental & clinical cancer research : CR · 2020Article
- Down-regulation of LINC00472 promotes osteosarcoma tumorigenesis by reducing FOXO1 expressions via miR-300.Cancer cell international · 2020Article
- miRNA signatures in childhood sarcomas and their clinical implications.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2019Review
- Bioinformatics Analysis Identifies MicroRNAs and Target Genes Associated with Prognosis in Patients with Melanoma.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- MicroRNA-300 inhibits the growth of hepatocellular carcinoma cells by downregulating CREPT/Wnt/β-catenin signaling.Oncology letters · 2019Article
Corrections and comments
- Retraction · 2022-06-08Duplication of/in Image · Investigation by Journal/Publisher · Paper Mill ·
- Retracted
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increasing reports suggest that deregulated microRNAs (miRNAs) might provide novel therapeutic targets for cancers. However, the expression and function of miR-300 in osteosarcoma is still unknown. In our study, we found that the expression of miR-300 was up-regulated in osteosarcoma tissues and cells compared with paired adjacent non-tumor bone tissues and osteoblastic cells using RT-qPCR. The enforced expression of miR-300 could promote cell proliferation, invasion and epithelial-mesenchymal transition (EMT). Moreover, we identified that bromodomain-containing protein 7 (BRD7), a new tumor suppressor gene, was a direct target of miR-300. Ectopic expression of BRD7 could significantly inhibit miR-300-promoted proliferation, invasion and EMT. Therefore, our results identify an important role for miR-300 in osteosarcoma through regulating BRD7 expression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.