Evidence map›Paper›PMID 26010484›Full record

ArticleBrain sciences2015

Association Study between the CD157/BST1 Gene and Autism Spectrum Disorders in a Japanese Population.

Shigeru Yokoyama, Naila Al Mahmuda, Toshio Munesue, Kenshi Hayashi, Kunimasa Yagi, Masakazu Yamagishi, Haruhiro Higashida

Open access · goldAbstract read
In one paragraph

Article in Brain sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 30 citations in OpenAlex.

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  10. One Single Nucleotide Polymorphism of theDiseases (Basel, Switzerland) · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Shigeru YokoyamaResearch Center for Child Mental Development, Kanazawa University, Kanazawa 920-8640, Japan. shigeruy@med.kanazawa-u.ac.jp.
Naila Al MahmudaResearch Center for Child Mental Development, Kanazawa University, Kanazawa 920-8640, Japan. naila@med.kanazawa-u.ac.jp.
Toshio MunesueResearch Center for Child Mental Development, Kanazawa University, Kanazawa 920-8640, Japan. munesue@med.kanazawa-u.ac.jp.
Kenshi HayashiDivision of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Japan. kenshi@med.kanazawa-u.ac.jp.
Kunimasa YagiMedical Education Research Center, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8640, Japan. diabe@med.kanazawa-u.ac.jp.
Masakazu YamagishiDivision of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Japan. myamagi@med.kanazawa-u.ac.jp.
Haruhiro HigashidaResearch Center for Child Mental Development, Kanazawa University, Kanazawa 920-8640, Japan. haruhiro@med.kanazawa-u.ac.jp.
Kanazawa University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CD157, also referred to as bone marrow stromal cell antigen-1 (BST-1), is a glycosylphosphatidylinositol-anchored molecule that promotes pre-B-cell growth. Previous studies have reported associations between single-nucleotide polymorphisms (SNPs) of the CD157/BST1 gene with Parkinson's disease. In an attempt to determine whether SNPs or haplotypes in the CD157/BST1 are associated with other brain disorders, we performed a case-control study including 147 autism spectrum disorder (ASD) patients at Kanazawa University Hospital in Japan and 150 unselected Japanese volunteers by the sequence-specific primer-polymerase chain reaction method combined with fluorescence correlation spectroscopy. Of 93 SNPs examined, two SNPs showed significantly higher allele frequencies in cases with ASDs than in unaffected controls (rs4301112, OR = 6.4, 95% CI = 1.9 to 22, p = 0.0007; and rs28532698, OR = 6.2, 95% CI = 1.8 to 21, p = 0.0012; Fisher's exact test; p < 0.002 was considered significant after multiple testing correction). In addition, CT genotype in rs10001565 was more frequently observed in the ASD group than in the control group (OR = 15, 95% CI = 2.0 to 117, p = 0.0007; Fisher's exact test). The present data indicate that genetic variation of the CD157/BST1 gene might confer susceptibility to ASDs.

Indexed as

autism spectrum disorderBST-1CD157single-nucleotide polymorphism

Identifiers

PMID26010484
PMCPMC4493464
OpenAlexW1582431600

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.