ArticlePloS one2015
Association between Dietary Magnesium Intake and Radiographic Knee Osteoarthritis.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- The relationship between magnesium and osteoarthritis of knee: A MOOSE guided systematic review and meta-analysis.Medicine · 2019Pooled it
- Analgesic effect and safety of single-dose intra-articular magnesium after arthroscopic surgery: a systematic review and meta-analysis.Scientific reports · 2016Pooled it
- [Research progress on the role and mechanism of magnesium element and magnesium materials in tendon-bone interface healing].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026Review
- Changes in the Concentration Profile of Selected Micro- and Macro-Elements in the Yellow Ligament Obtained from Patients with Degenerative Stenosis of the Lumbo-Sacral Spine.Journal of clinical medicine · 2025Article
- Elemental imbalance and oxidative biomarker shifts in lumbar disc degeneration.Frontiers in neurology · 2025Article
- Association of magnesium deficiency scores with risk of rheumatoid arthritis and osteoarthritis in adults: a cross-sectional population-based study.Clinical rheumatology · 2024Article
- Evaluation of the Concentration of Selected Elements in the Serum of Patients with Degenerative Stenosis of the Lumbosacral Spine.Biological trace element research · 2024Article
- Omeprazole and risk of osteoarthritis: insights from a mendelian randomization study in the UK Biobank.Journal of translational medicine · 2024Article
- Changes in Elements and Relationships among Elements in Intervertebral Disc Degeneration.International journal of environmental research and public health · 2022Article
- Increased Wnt/β-catenin signaling contributes to autophagy inhibition resulting from a dietary magnesium deficiency in injury-induced osteoarthritis.Arthritis research & therapy · 2022Article
- Proton pump inhibitor therapy and risk of knee replacement surgery: a general population-based cohort study.Osteoarthritis and cartilage · 2022Article
- Association between egg consumption and metabolic syndrome in Chinese population: a cross-sectional study.BMJ open · 2021Article
- Disease-Modifying Adjunctive Therapy (DMAT) in Osteoarthritis-The Biological Effects of a Multi-Mineral Complex, LithoLexalClinics and practice · 2021Review
- Comparison of Bone Tissue Trace Element Content in the Different Radiological Stages of Hip Osteoarthritis.International journal of environmental research and public health · 2021Article
- The Impact of Trace Elements on Osteoarthritis.Frontiers in medicine · 2021Review
- Micronutrients: Essential Treatment for Inflammatory Arthritis?Current rheumatology reports · 2020Review
- Effects of Balneotherapy in Jeju Magma-Seawater on Knee Osteoarthritis Model.Scientific reports · 2020Article
- Article
- The Association between Dietary Magnesium Intake and Magnetic Resonance Parameters for Knee Osteoarthritis.Nutrients · 2019Article
- Vitamin D in the Prevention and Treatment of Osteoarthritis: From Clinical Interventions to Cellular Evidence.Nutrients · 2019Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo examine the cross-sectional associations between dietary magnesium (Mg) intake and radiographic knee osteoarthritis (OA), joint space narrowing (JSN), and osteophytes (OST) respectively.
methodsA total of 1626 subjects were included in the study. Dietary intake was assessed using a validated semi-quantitative food frequency questionnaire. Radiographic knee OA was defined as Kellgren-Lawrence (K-L) Grade 2 in at least one leg. JSN and OST were assessed individually according to the Osteoarthritis Research Society International (OARSI) atlas. A multivariable logistic analysis model was applied to test the various associations after adjusting for potentially confounding factors.
resultsThe relative odds of radiographic knee OA were decreased by 0.53 times in the third quintile of Mg intake [odds ratio (OR) 0.53, 95% confidence interval (CI) 0.28-1.01], 0.40 times in the fourth quintile (OR 0.40, 95% CI 0.17-0.94) and 0.34 times in the fifth quintile (OR 0.34, 95% CI 0.11-1.00) compared with those in the lowest quintile, while P for trend was 0.111. The relative odds of JSN were decreased by 0.49 times in the third quintile of Mg intake (OR 0.49, 95% CI 0.28-0.88) and 0.37 times in the fifth quintile (OR 0.37, 95% CI 0.14-0.98) compared with those in the lowest quintile, while P for trend was 0.088. There was no significant relationship between dietary Mg intake and the presence of OST.
conclusionsThe findings of this cross-sectional study indicate that Mg intake is inversely associated with radiographic knee OA and JSN. It supports potential role of Mg in the prevention of knee OA. LEVEL OF EVIDENCE: LevelIII, cross-sectional study.
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