ArticleThe American journal of gastroenterology2015
A Risk Prediction Index for Advanced Colorectal Neoplasia at Screening Colonoscopy.
Article in The American journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01596582 (Impact of Risk Stratification on Shared Decision-Making for Colorectal Cancer Screening), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Risk Stratification on Shared Decision-Making for Colorectal Cancer Screening
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Risk Scores for Predicting Advanced Colorectal Neoplasia in the Average-risk Population: A Systematic Review and Meta-analysis.The American journal of gastroenterology · 2018Pooled it
- Trial
- Risk Stratification and Shared Decision Making for Colorectal Cancer Screening: A Randomized Controlled Trial.Medical decision making : an international journal of the Society for Medical Decision Making · 2016Trial
- Interrogating the Mechanistic Link between Neighborhood Deprivation and Colorectal Cancer Risk through Transcriptomic Analysis of Normal Colorectal Biopsies.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026Article
- The impact of adherence on colorectal cancer screening cost-effectiveness: A modeling study.PLoS medicine · 2025Article
- Risk prediction of advanced colorectal neoplasia varies by race and neighbourhood socioeconomic status.Family medicine and community health · 2024Article
- Colorectal Cancer Risk Assessment and Precision Approaches to Screening: Brave New World or Worlds Apart?Gastroenterology · 2023Review
- Designing a Predictive Model for Colorectal Neoplasia Diagnosis Based on Clinical and Laboratory Findings in Colonoscopy Candidate Patients.Journal of gastrointestinal cancer · 2022Article
- Non-invasive model for predicting esophageal varices based on liver and spleen volume.World journal of clinical cases · 2022Article
- A scoping review of risk-stratified bowel screening: current evidence, future directions.Cancer causes & control : CCC · 2022Article
- Development of a Large Colonoscopy-Based Longitudinal Cohort for Integrated Research of Colorectal Cancer: Partners Colonoscopy Cohort.Digestive diseases and sciences · 2022Article
- A risk-prediction score for colorectal lesions on 12,628 participants at high risk of colorectal cancer.Gastroenterology report · 2022Article
- Application of deep learning to predict advanced neoplasia using big clinical data in colorectal cancer screening of asymptomatic adults.The Korean journal of internal medicine · 2021Article
- Deep Neural Network-Based Prediction of the Risk of Advanced Colorectal Neoplasia.Gut and liver · 2021Article
- Risk prediction rule for advanced neoplasia on screening colonoscopy for average-risk individuals.World journal of gastroenterology · 2020Article
- A healthy lifestyle pattern has a protective association with colorectal polyps.European journal of clinical nutrition · 2020Article
- Association of Cardiovascular Risk Assessment with Early Colorectal Neoplasia Detection in Asymptomatic Population: A Systematic Review and Meta-Analysis.Clinical epidemiology · 2020Review
- Head-to-Head Comparison of the Performance of 17 Risk Models for Predicting Presence of Advanced Neoplasms in Colorectal Cancer Screening.The American journal of gastroenterology · 2019Article
- Clinical risk stratification model for advanced colorectal neoplasia in persons with negative fecal immunochemical test results.PloS one · 2018Article
- Impact of Age on the Risk of Advanced Colorectal Neoplasia in a Young Population: An Analysis Using the Predicted Probability Model.Digestive diseases and sciences · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectivesEliciting patient preferences within the context of shared decision making has been advocated for colorectal cancer screening. Risk stratification for advanced colorectal neoplasia (ACN) might facilitate more effective shared decision making when selecting an appropriate screening option. Our objective was to develop and validate a clinical index for estimating the probability of ACN at screening colonoscopy.
methodsWe conducted a cross-sectional analysis of 3,543 asymptomatic, mostly average-risk patients 50-79 years of age undergoing screening colonoscopy at two urban safety net hospitals. Predictors of ACN were identified using multiple logistic regression. Model performance was internally validated using bootstrapping methods.
resultsThe final index consisted of five independent predictors of risk (age, smoking, alcohol intake, height, and a combined sex/race/ethnicity variable). Smoking was the strongest predictor (net reclassification improvement (NRI), 8.4%) and height the weakest (NRI, 1.5%). Using a simplified weighted scoring system based on 0.5 increments of the adjusted odds ratio, the risk of ACN ranged from 3.2% (95% confidence interval (CI), 2.6-3.9) for the low-risk group (score ≤2) to 8.6% (95% CI, 7.4-9.7) for the intermediate/high-risk group (score 3-11). The model had moderate to good overall discrimination (C-statistic, 0.69; 95% CI, 0.66-0.72) and good calibration (P=0.73-0.93).
conclusionsA simple 5-item risk index based on readily available clinical data accurately stratifies average-risk patients into low- and intermediate/high-risk categories for ACN at screening colonoscopy. Uptake into clinical practice could facilitate more effective shared decision-making for CRC screening, particularly in situations where patient and provider test preferences differ.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.