Trial reportInternational forum of allergy & rhinology2015
Volumetric computed tomography analysis of the olfactory cleft in patients with chronic rhinosinusitis.
Trial report in International forum of allergy & rhinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06082193 (Olfactory Cleft Stenosis and Obstruction on Paranasal Sinus CT Scan in Pre Septo Rhinoplasty Patients Without Respiratory Mucosa Pathology), which is not on this map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Olfactory Cleft Stenosis and Obstruction on Paranasal Sinus CT Scan in Pre Septo Rhinoplasty Patients Without Respiratory Mucosa Pathology : Normal Variants or Pathologic Findings ?
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The prevalence of olfactory dysfunction in chronic rhinosinusitis.The Laryngoscope · 2017Pooled it
- Reversible obstruction of the olfactory cleft: impact on olfactory perception and nasal patency.International forum of allergy & rhinology · 2020Trial
- Olfactory cleft evaluation: a predictor for olfactory function in smell-impaired patients?European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2018Trial
- Conductive Mechanisms of Olfactory Dysfunction in Chronic Rhinosinusitis: A Focus on Nasal Airflow Dynamics and Olfactory Mucus.Clinical reviews in allergy & immunology · 2026Review
- Explainable hybrid CNN-transformer with self-supervised learning for structural analysis of paranasal sinus CT.Frontiers in computational neuroscience · 2026Article
- Comparison of segmentation performance of cnns, vision transformers, and hybrid networks for paranasal sinuses with sinusitis on CT images.Scientific reports · 2025Article
- The impact of highly effective modulator therapy on sinusitis and dysosmia in young children with cystic fibrosis: a prospective study protocol.ERJ open research · 2025Article
- Development and validation of a nomogram model for the prediction of recurrence after endoscopic sinus surgery in patients with chronic rhinosinusitis with nasal polyps.Frontiers in surgery · 2025Article
- Propriety of various examinations for subjective symptoms of olfactory disorders.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Article
- Olfactory cleft stenosis and obstruction on paranasal sinus CT scan in pre-septo-rhinoplasty patients: normal variants or pathologic findings?European radiology · 2024Article
- Predictive significance of the questionnaire of olfactory disorders-negative statements for olfactory loss in patients with chronic rhinosinusitis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022Article
- Article
- Analyses on the influence of normal nasal morphological variations on odorant transport to the olfactory cleft.Inhalation toxicology · 2022Article
- Computational Analysis of Olfactory Airspace in Patients With Unilateral Cleft Lip Nasal Deformity.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2021Article
- The Olfactory Cleft Endoscopy Scale: a multi-institutional validation study in chronic rhinosinusitis.Rhinology · 2021Article
- Role of nasal vestibule morphological variations on olfactory airflow dynamics.Clinical biomechanics (Bristol, Avon) · 2021Article
- Olfaction: Sensitive indicator of inflammatory burden in chronic rhinosinusitis.Laryngoscope investigative otolaryngology · 2020Review
- Radiological Markers of the Olfactory Cleft: Relations to Unilateral Orthonasal and Retronasal Olfactory Function.Diagnostics (Basel, Switzerland) · 2020Article
- Olfactory cleft and sinus opacification differentially impact olfaction in chronic rhinosinusitis.The Laryngoscope · 2020Article
- Correlation of mucus inflammatory proteins and olfaction in chronic rhinosinusitis.International forum of allergy & rhinology · 2020Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundCommonly used computed tomography (CT) staging systems for chronic rhinosinusitis (CRS) focus on the sinuses and do not quantify disease in the olfactory cleft. The goal of the current study was to determine whether precise measurements of olfactory cleft opacification better correlate with olfaction in patients with CRS.
methodsOlfaction was assessed using the 40-item Smell Identification Test (SIT-40) before and after sinus surgery in adult patients. Olfactory cleft opacification was quantified precisely using three-dimensional (3D), computerized volumetric analysis, as well as via semiquantitative Likert scale estimations at predetermined anatomic sites. Sinus opacification was also quantified using the Lund-Mackay staging system.
resultsThe overall cohort (n = 199) included 89 (44.7%) patients with CRS with nasal polyposis (CRSwNP) and 110 (55.3%) with CRS without nasal polyposis (CRSsNP). The olfactory cleft opacified volume correlated with objective olfaction as determined by the SIT-40 (Spearman's rank correlation coefficient [Rs ] = -0.461; p < 0.001). The correlation was significantly stronger in the CRSwNP subgroup (Rs = -0.573; p < 0.001), whereas no appreciable correlation was found in the CRSsNP group (Rs = -0.141; p = 0.141). Correlations between sinus-specific Lund-Mackay CT scoring and SIT-40 scores were weaker in the CRSwNP (Rs = -0.377; p < 0.001) subgroup but stronger in the CRSsNP (Rs = -0.225; p = 0.018) group when compared to olfactory cleft correlations. Greater intraclass correlations (ICCs) were found between quantitative volumetric measures of olfactory cleft opacification (ICC = 0.844; p < 0.001) as compared with semiquantitative Likert grading (ICC = 0.627; p < 0.001).
conclusionQuantitative measures of olfactory cleft opacification correlate with objective olfaction, with the strongest correlations seen in patients with nasal polyps.
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