ArticlePloS one2015
Reverse Correlation between MicroRNA-145 and FSCN1 Affecting Gastric Cancer Migration and Invasion.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- MiR-145 encapsulated small extracellular vesicles inhibit colorectal cancer progression by downregulating fascin actin-bundling protein 1 expression.Stem cell research & therapy · 2025Article
- FSCN1 has a potential indication for the prognosis and regulates the migration of HNSCC.Cancer biomarkers : section A of Disease markers · 2023Article
- Review
- Vitamin D modulation and microRNAs in gastric cancer: prognostic and therapeutic role.Translational cancer research · 2021Review
- Fascin actin-bundling protein 1 in human cancer: promising biomarker or therapeutic target?Molecular therapy oncolytics · 2021Review
- Inhibition of circRNA circVPS33B Reduces Warburg Effect and Tumor Growth Through Regulating the miR-873-5p/HNRNPK Axis in Infiltrative Gastric Cancer.OncoTargets and therapy · 2021Article
- Article
- MicroRNA‑145‑5p suppresses fascin to inhibit the invasion and migration of cervical carcinoma cells.Molecular medicine reports · 2020Article
- Identification of the Combinatorial Effect of miRNA Family Regulatory Network in Different Growth Patterns of GC.Molecular therapy oncolytics · 2020Article
- MiR-145: a potential biomarker of cancer migration and invasion.American journal of translational research · 2019Review
- Evaluation of circulating small extracellular vesicles derived miRNAs as biomarkers of early colon cancer: a comparison with plasma total miRNAs.Journal of extracellular vesicles · 2019Article
- MicroRNA Expression Profiles in Gastric Carcinogenesis.Scientific reports · 2018Article
- Regulatory network of circRNA-miRNA-mRNA contributes to the histological classification and disease progression in gastric cancer.Journal of translational medicine · 2018Article
- SEC24A stimulates oncogenicity of human gastric cancer cells.International journal of clinical and experimental pathology · 2018Article
- The comprehensive expression analysis of circular RNAs in gastric cancer and its association with field cancerization.Scientific reports · 2017Article
- Identification of the key miRNAs associated with survival time in stomach adenocarcinoma.Oncology letters · 2017Article
- Plasma miR-145 as a novel biomarker for the diagnosis and radiosensitivity prediction of human cervical cancer.The Journal of international medical research · 2017Article
- miR-539 inhibits FSCN1 expression and suppresses hepatocellular carcinoma migration and invasion.Oncology reports · 2017Article
- MicroRNA-145 exerts tumor-suppressive and chemo-resistance lowering effects by targeting CD44 in gastric cancer.World journal of gastroenterology · 2017Article
- Expression and function of the miR-143/145 cluster in vitro and in vivo in human breast cancer.PloS one · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs (miRs) play important roles in modulating gene expression during the processes of tumorigenesis and tumor development. Previous studies have found that miR-145 is down-regulated in the stomach neoplasm and is related to tumor migration and invasion. However, both the molecular mechanism and function of miR-145 in gastric cancer remain unclear. The present study is the first demonstration of the significant down-regulation of miR-145 expression in infiltrative gastric cancer compared to expanding gastric cancer. Additionally, correlation analyses revealed strong inverse correlations between miR-145 and FSCN1 expression levels in infiltrative gastric cancer. Furthermore, we demonstrated that miR-145 directly targets FSCN1 and suppresses cell migration and invasion in gastric cancer. Knocking down the expression of FSCN1 led to the suppression of migration and invasion in gastric cancer cells, and re-expressing FSCN1 in miR-145-overexpressing cells reversed their migration and invasion defects. Thus, we concluded that miR-145 regulates cell migration and invasion in gastric cancer primarily by directly targeting FSCN1.
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