Evidence map›Paper›PMID 26010092›Full record

ArticlePloS one2015

Effect of neonatal asphyxia on the impairment of the auditory pathway by recording auditory brainstem responses in newborn piglets: a new experimentation model to study the perinatal hypoxic-ischemic damage on the auditory system.

Francisco Jose Alvarez, Miren Revuelta, Francisco Santaolalla, Antonia Alvarez, Hector Lafuente, Olatz Arteaga, Daniel Alonso-Alconada, Ana Sanchez-del-Rey, Enrique Hilario, Agustin Martinez-Ibargüen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Francisco Jose AlvarezResearch Unit on Experimental Perinatal Physiopathology, Cruces University Hospital, Barakaldo, 48080, Bizkaia, Spain.
Miren RevueltaDepartment of Cell Biology and Histology, Faculty of Medicine and Dentistry, University of the Basque Country, Barrio Sarriena s/n, Leioa, 48940, Bizkaia, Spain.
Francisco SantaolallaDepartment of Otorhinolaryngology, Basurto University Hospital, Faculty of Medicine, University of the Basque Country, Barrio Sarriena s/n, Leioa, 48940, Bizkaia, Spain.
Antonia AlvarezDepartment of Cell Biology and Histology, Faculty of Medicine and Dentistry, University of the Basque Country, Barrio Sarriena s/n, Leioa, 48940, Bizkaia, Spain.
Hector LafuenteResearch Unit on Experimental Perinatal Physiopathology, Cruces University Hospital, Barakaldo, 48080, Bizkaia, Spain.
Olatz ArteagaDepartment of Cell Biology and Histology, Faculty of Medicine and Dentistry, University of the Basque Country, Barrio Sarriena s/n, Leioa, 48940, Bizkaia, Spain.
Daniel Alonso-AlconadaDepartment of Cell Biology and Histology, Faculty of Medicine and Dentistry, University of the Basque Country, Barrio Sarriena s/n, Leioa, 48940, Bizkaia, Spain.
Ana Sanchez-del-ReyDepartment of Otorhinolaryngology, Basurto University Hospital, Faculty of Medicine, University of the Basque Country, Barrio Sarriena s/n, Leioa, 48940, Bizkaia, Spain.
Enrique HilarioDepartment of Cell Biology and Histology, Faculty of Medicine and Dentistry, University of the Basque Country, Barrio Sarriena s/n, Leioa, 48940, Bizkaia, Spain.
Agustin Martinez-IbargüenDepartment of Otorhinolaryngology, Basurto University Hospital, Faculty of Medicine, University of the Basque Country, Barrio Sarriena s/n, Leioa, 48940, Bizkaia, Spain.
University of the Basque Country · ESHospital de Cruces · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHypoxia-ischemia (HI) is a major perinatal problem that results in severe damage to the brain impairing the normal development of the auditory system. The purpose of the present study is to study the effect of perinatal asphyxia on the auditory pathway by recording auditory brain responses in a novel animal experimentation model in newborn piglets.

methodHypoxia-ischemia was induced to 1.3 day-old piglets by clamping 30 minutes both carotid arteries by vascular occluders and lowering the fraction of inspired oxygen. We compared the Auditory Brain Responses (ABRs) of newborn piglets exposed to acute hypoxia/ischemia (n = 6) and a control group with no such exposure (n = 10). ABRs were recorded for both ears before the start of the experiment (baseline), after 30 minutes of HI injury, and every 30 minutes during 6 h after the HI injury.

resultsAuditory brain responses were altered during the hypoxic-ischemic insult but recovered 30-60 minutes later. Hypoxia/ischemia seemed to induce auditory functional damage by increasing I-V latencies and decreasing wave I, III and V amplitudes, although differences were not significant.

conclusionThe described experimental model of hypoxia-ischemia in newborn piglets may be useful for studying the effect of perinatal asphyxia on the impairment of the auditory pathway.

Indexed as

Evoked Potentials, Auditory, Brain StemAnimalsAnimals, NewbornAsphyxiaAuditory PathwaysDisease Models, AnimalHumansHypoxia-Ischemia, BrainReaction Time

Identifiers

PMID26010092
PMCPMC4444324
OpenAlexW2255240008

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.