ArticleLab on a chip2015
Multiplexed paper analytical device for quantification of metals using distance-based detection.
Article in Lab on a chip, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 243 citations in OpenAlex.
- CRISPR-Programmable Nanoparticle Transport in Salt-Gated Porous Media for Visual DNA Detection.Chemical engineering journal (Lausanne, Switzerland : 1996) · 2026Article
- Capillary-driven distance-based paper analytical devices for albumin protein and glucose quantification in human whole blood.Mikrochimica acta · 2025Article
- Real-World Implementation of Particle-Based Microfluidics: On-Spot Test for Iron and Copper Ions in Water.ACS omega · 2025Article
- Distance-based paper microfluidic devices for rapid visual quantification of heavy metals in herbal supplements and cosmetics.RSC advances · 2024Article
- Distance-based analytical device integrated with carbon nanomaterials for sarcosine quantification in human samples.Mikrochimica acta · 2024Article
- Skin-Interfaced Bifluidic Paper-Based Device for Quantitative Sweat Analysis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Research advances in microfluidic collection and detection of virus, bacterial, and fungal bioaerosols.Mikrochimica acta · 2024Review
- A Facile Method to Fabricate an Enclosed Paper-Based Analytical Device via Double-Sided Patterning for Ionic Contaminant Detection.Biosensors · 2023Article
- Screen Printed Particle-Based Microfluidics: Optimization and Exemplary Application for Heavy Metals Analysis.Micromachines · 2023Article
- Accuracy improvementRSC advances · 2023Article
- A Dihydropyridine Derivative as a Highly Selective Fluorometric Probe for Quantification of AuSensors (Basel, Switzerland) · 2022Article
- Semi-quantitative analysis of nickel: counting-based μPADs builtRSC advances · 2022Article
- Modification of Microfluidic Paper-Based Devices with an Oxidant Layer for Distance Readout of Reducing Substances.ACS omega · 2022Article
- Lab-on-a-Chip Platforms for Airborne Particulate Matter Applications: A Review of Current Perspectives.Biosensors · 2022Review
- Ball pen writing-without-ink: a truly simple and accessible method for sensitivity enhancement in lateral flow assays.RSC advances · 2022Article
- Recent Developments in Microfluidic Paper-based Analytical Devices for Pharmaceutical Analysis.Current topics in medicinal chemistry · 2022Article
- Simple, fast, and instrumentless fabrication of paper analytical devices by novel contact stamping method based on acrylic varnish and 3D printing.Mikrochimica acta · 2021Article
- Recent Analytical Method for Detection of Chemical Adulterants in Herbal Medicine.Molecules (Basel, Switzerland) · 2021Review
- Quantitative Point-of-Care Colorimetric Assay Modeling Using a Handheld Colorimeter.ACS omega · 2021Article
- Highly selective simultaneous determination of Cu(ii), Co(ii), Ni(ii), Hg(ii), and Mn(ii) in water samples using microfluidic paper-based analytical devices.The Analyst · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Exposure to metal-containing aerosols has been linked with adverse health outcomes for almost every organ in the human body. Commercially available techniques for quantifying particulate metals are time-intensive, laborious, and expensive; often sample analysis exceeds $100. We report a simple technique, based upon a distance-based detection motif, for quantifying metal concentrations of Ni, Cu, and Fe in airborne particulate matter using microfluidic paper-based analytical devices. Paper substrates are used to create sensors that are self-contained, self-timing, and require only a drop of sample for operation. Unlike other colorimetric approaches in paper microfluidics that rely on optical instrumentation for analysis, with distance-based detection, analyte is quantified visually based on the distance of a colorimetric reaction, similar to reading temperature on a thermometer. To demonstrate the effectiveness of this approach, Ni, Cu, and Fe were measured individually in single-channel devices; detection limits as low as 0.1, 0.1, and 0.05 μg were reported for Ni, Cu, and Fe. Multiplexed analysis of all three metals was achieved with detection limits of 1, 5, and 1 μg for Ni, Cu, and Fe. We also extended the dynamic range for multi-analyte detection by printing concentration gradients of colorimetric reagents using an off-the-shelf inkjet printer. Analyte selectivity was demonstrated for common interferences. To demonstrate utility of the method, Ni, Cu, and Fe were measured from samples of certified welding fume; levels measured with paper sensors matched known values determined gravimetrically.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.