Evidence map›Paper›PMID 26009885›Full record

SynthesisPloS one2015

Efficacy of thermotherapy to treat cutaneous leishmaniasis: a meta-analysis of controlled clinical trials.

Jaiberth Antonio Cardona-Arias, Iván Darío Vélez, Liliana López-Carvajal

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Interventions for American cutaneous and mucocutaneous leishmaniasis.The Cochrane database of systematic reviews · 2020
    Pooled it
  3. Pooled it
  4. Trial
  5. Efficacy, Safety and Cost-Effectiveness of Thermotherapy in the Treatment ofThe American journal of tropical medicine and hygiene · 2017
    Trial
  6. Trial
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. [Cutaneous leishmaniasis in Germany-still a travel-related disease].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2022
    Review
  13. Article
  14. Article
  15. Leishmaniasis.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2021
    Article
  16. Heat therapy for cutaneous leishmaniasis: A literature Review.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2021
    Review
  17. Review
  18. Review
  19. Observational
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jaiberth Antonio Cardona-AriasMicrobiologist and Bioanalyst, School of Medicine, Cooperative University of Colombia, Medellín, Antioquia, Colombia; School of Microbiology, University of Antioquia UofA, 70 Street # 52-21, Medellin, Colombia.
Iván Darío VélezPECET, University of Antioquia, Medellin, Colombia.
Liliana López-CarvajalEpidemiology, PECET, University of Antioquia, Medellin, Colombia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe efficacy of thermotherapy for the treatment of cutaneous leishmaniasis presents diverse results with low statistical power.

objectiveTo evaluate the efficacy of thermotherapy to treat cutaneous leishmaniasis.

methodsA meta-analysis of controlled clinical trials in 12 databases based on the implementation of a research protocol with inclusion and exclusion criteria and an assessment of methodological quality. The reproducibility and completeness were guaranteed in the information search and extraction. Heterogeneity, sensitivity and publication bias were assessed by graphical methods (Galbraith, L'Abblé, funnel plot, Egger plot, and influence plot) and analytical methods (DerSimonian-Laird, Begg and Egger). Random-effects forest plots were constructed, and a cumulative meta-analysis was performed.

resultsEight studies were included with 622 patients who underwent thermotherapy, with an efficacy of 73.2% (95% confidence interval (CI) = 69.6-76.7%), and with 667 patients who underwent systemic treatment, with an efficacy of 70.6% (95% CI=67.1-74.1%). Heterogeneity between studies, good sensitivity for the combined measure, and no publication bias were observed. The relative risk for comparison of the efficacy of treatment was 1.02 (95%CI=0.91, 1.15), showing that the effectiveness of thermotherapy is equal to that of pentavalent antimonial drugs.

conclusionDue to its efficacy, greater safety and lower cost, thermotherapy should be the first treatment option for cutaneous leishmaniasis in areas where the prevalence of the mucocutaneous form is low and in patients with contraindications to systemic treatment, such as kidney, liver and heart diseases, as well as in pregnant women, infants, and patients with human immunodeficiency virus infection/acquired immune deficiency syndrome.

Indexed as

Controlled Clinical Trials as TopicHyperthermia, InducedConfidence IntervalsHumansLeishmaniasis, CutaneousMeglumineMeglumine AntimoniateModels, BiologicalOrganometallic CompoundsTreatment OutcomeMeglumineMeglumine AntimoniateOrganometallic Compounds

Identifiers

PMID26009885
PMCPMC4444239

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.