Evidence map›Paper›PMID 26009838›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2015

Implementation and Operational Research: Uptake of Services and Behaviors in the Prevention of Mother-to-Child HIV Transmission Cascade in Zimbabwe.

Sandra I McCoy, Raluca Buzdugan, Nancy S Padian, Reuben Musarandega, Barbara Engelsmann, Tyler E Martz, Angela Mushavi, Agnes Mahomva, Frances M Cowan

Abstract read
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sandra I McCoy*Division of Epidemiology, School of Public Health, University of California, Berkeley, CA; †Elizabeth Glaser Pediatric AIDS Foundation, Harare, Zimbabwe; ‡Organisation for Public Health Interventions and Development (OPHID) Trust, Harare, Zimbabwe; §Ministry of Health and Child Care, Harare, Zimbabwe; ‖Centre for Sexual Health and HIV Research, Zimbabwe; ¶University College London, London, United Kingdom.
Raluca Buzdugan
Nancy S Padian
Reuben Musarandega
Barbara Engelsmann
Tyler E Martz
Angela Mushavi
Agnes Mahomva
Frances M Cowan

Funding

Evaluation of the Population-level Impact of PMTCT Option B+ in ZimbabweR01HD080492 · NICHD · UNIVERSITY OF CALIFORNIA BERKELEY · PI COWAN, FRANCES MARY, PADIAN, NANCY · 2014 to 2018
$2.4M
Agricultural Livelihoods, Food Security, and Women's Risk of HIV InfectionK01MH094246 · NIMH · UNIVERSITY OF CALIFORNIA BERKELEY · PI MCCOY, SANDRA I · 2011 to 2015
$1.0M
NICHD NIH HHS R01 HD080492NIMH NIH HHS K01 MH094246NIMH NIH HHS K01MH094246
6 · The paper itself

Abstract

objectiveTo examine the uptake of services and behaviors in the prevention of mother-to-child HIV transmission (PMTCT) cascade in Zimbabwe and to determine factors associated with MTCT and maternal antiretroviral therapy (ART) or antiretroviral (ARV) prophylaxis.

designAnalysis of cross-sectional data from mother-infant pairs.

methodsWe analyzed baseline data collected in 2012 as part of the impact evaluation of Zimbabwe's Accelerated National PMTCT Program. Using multistage cluster sampling, eligible mother-infant pairs were randomly sampled from the catchment areas of 157 facilities in 5 provinces, tested for HIV infection, and interviewed about PMTCT service utilization.

resultsOf 8800 women, 94% attended ≥ 1 antenatal care visit, 92% knew their HIV serostatus during pregnancy, 77% delivered in a health facility, and 92% attended the 6-8 week postnatal visit. Among 1075 (12%) HIV-infected women, 59% reported ART/ARV prophylaxis and 63% of their HIV-exposed infants received ARV prophylaxis. Among HIV-exposed infants, maternal receipt of ART/ARV prophylaxis was protective against MTCT [adjusted prevalence ratio (PR(a)): 0.41, 95% confidence interval (CI): 0.23 to 0.74]. Factors associated with receipt of maternal ART/ARV prophylaxis included ≥ 4 antenatal care visits (PR(a): 1.18, 95% CI: 1.01 to 1.38), institutional delivery (PR(a): 1.31, 95% CI: 1.13 to 1.52), and disclosure of serostatus (PRa: 1.30, 95% CI: 1.12 to 1.49).

conclusionsThese data from women in the community indicate gaps in the PMTCT cascade before the accelerated program, which may have been missed by examination of health facility data alone. These gaps were especially noteworthy for services targeted specifically to HIV-infected women and their infants, such as maternal and infant ART/ARV prophylaxis.

Indexed as

Patient Acceptance of Health CareAdolescentAdultAnti-Retroviral AgentsChemopreventionCross-Sectional StudiesData CollectionFemaleHIV InfectionsHumansInfantInfant, NewbornInfectious Disease Transmission, VerticalPregnancyPregnancy Complications, InfectiousPublic Health AdministrationAnti-Retroviral Agents

Identifiers

PMID26009838
PMCPMC4445469

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.