ArticleShock (Augusta, Ga.)2015
Severe Burn Injury Induces Thermogenically Functional Mitochondria in Murine White Adipose Tissue.
Article in Shock (Augusta, Ga.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 46 citations in OpenAlex.
- Mitochondria as a Therapeutic Target for Burn Injury.Biomolecules · 2026Review
- HOUSING TEMPERATURE ALTERS BURN-INDUCED HYPERMETABOLISM IN MICE.Shock (Augusta, Ga.) · 2025Article
- The Different Shades of Thermogenic Adipose Tissue.Current obesity reports · 2024Review
- Changes in brown adipose tissue induced by resveratrol and its analogue pterostilbene in rats fed with a high-fat high-fructose diet.Journal of physiology and biochemistry · 2024Article
- Subcutaneous white adipose tissue independently regulates burn-induced hypermetabolism via immune-adipose crosstalk.Cell reports · 2024Article
- Hyperactive browning and hypermetabolism: potentially dangerous element in critical illness.Frontiers in endocrinology · 2024Review
- Review
- [A brief discussion on precision nutrition support for severe burn patients from theory to practice].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2022Article
- LncRNA-Mediated Adipogenesis in Different Adipocytes.International journal of molecular sciences · 2022Review
- Article
- Lactate Fluxes and Plasticity of Adipose Tissues: A Redox Perspective.Frontiers in physiology · 2021Review
- TheCells · 2020Article
- Brown adipose tissue recruitment in a rodent model of severe burns.Burns : journal of the International Society for Burn Injuries · 2020Article
- The emerging roles of lactate as a redox substrate and signaling molecule in adipose tissues.Journal of physiology and biochemistry · 2020Review
- Activation of Anxiogenic Circuits Instigates Resistance to Diet-Induced Obesity via Increased Energy Expenditure.Cell metabolism · 2019Article
- Adipose tissue uncoupling protein 1 levels and function are increased in a mouse model of developmental obesity induced by maternal exposure to high-fat diet.Journal of developmental origins of health and disease · 2018Article
- Burn Trauma Acutely Increases the Respiratory Capacity and Function of Liver Mitochondria.Shock (Augusta, Ga.) · 2018Article
- The Role of Mitochondrial Stress in Muscle Wasting Following Severe Burn Trauma.Journal of burn care & research : official publication of the American Burn Association · 2018Review
- The response of muscle progenitor cells to cutaneous thermal injury.Stem cell research & therapy · 2017Article
- Quantification of UCP1 function in human brown adipose tissue.Adipocyte · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Chronic cold exposure induces functionally thermogenic mitochondria in the inguinal white adipose tissue (iWAT) of mice. Whether this response occurs in pathophysiological states remains unclear. The purpose of this study was to determine the impact of severe burn trauma on iWAT mitochondrial function in mice. Male BALB/c mice (10-12 weeks) received full-thickness scald burns to ∼30% of the body surface area. Inguinal white adipose tissue was harvested from mice at 1, 4, 10, 20, and 40 days postinjury. Total and uncoupling protein 1 (UCP1)-dependent mitochondrial thermogenesis were determined in iWAT. Citrate synthase activity was determined as a proxy of mitochondrial abundance. Immunohistochemistry was performed to assess iWAT morphology and UCP1 expression. Uncoupling protein 1-dependent respiration was significantly greater at 4 and 10 days after burn compared with sham, peaking at 20 days after burn (P < 0.001). Citrate synthase activity was threefold greater at 4, 10, 20, and 40 days after burn versus sham (P < 0.05). Per mitochondrion, UCP1 function increased after burn trauma (P < 0.05). After burn trauma, iWAT exhibited numerous multilocular lipid droplets that stained positive for UCP1. The current findings demonstrate the induction of thermogenically competent mitochondria within rodent iWAT in a model of severe burn trauma. These data identify a specific pathology that induces the browning of white adipose tissue in vivo and may offer a mechanistic explanation for the chronic hypermetabolism observed in burn victims.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.