ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2015
Serotonin release from the neuronal cell body and its long-lasting effects on the nervous system.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Serotonergic Signaling Rewired: A Lipid Raft-Controlled Model of Synaptic Transmission Grounded in the Fundamental Parameters of Biological Systems.Life (Basel, Switzerland) · 2026Article
- Riboflavin (Vitamin B2) Accumulation Modulates Neuronal Cellular Homeostasis in Typical Brain Development and Cerebral Palsy.Neurochemical research · 2025Article
- Role of Serotonergic System in Regulating Brain Tumor-Associated Neuroinflammatory Responses.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Navigating Like a Fly:International journal of molecular sciences · 2023Review
- Mitochondrial Dysfunction Links to Impaired Hippocampal Serotonin Release in a Mouse Model of Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2023Article
- The Thermodynamically Expensive Contribution of Three Calcium Sources to Somatic Release of Serotonin.International journal of molecular sciences · 2022Review
- Initial Variability and Time-Dependent Changes of Neuronal Response Features Are Cell-Type-Specific.Frontiers in cellular neuroscience · 2022Article
- Lactiplantibacillus plantarum LRCC5314 includes a gene for serotonin biosynthesis via the tryptophan metabolic pathway.Journal of microbiology (Seoul, Korea) · 2021Article
- Altered Membrane Mechanics Provides a Receptor-Independent Pathway for Serotonin Action.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Transcriptional profiling of identified neurons in leech.BMC genomics · 2021Article
- FGF13 Is Required for Histamine-Induced Itch Sensation by Interaction with NaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Prelimbic Cortical Stimulation Improves Spatial Memory Through Distinct Patterns of Hippocampal Gene Expression in Aged Rats.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020Article
- Serotonin induces or inhibits neuritic regeneration of leech CNS neurons depending on neuronal identity.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2019Article
- Biphasic Effect of Buspirone on the H-Reflex in Acute Spinal Decerebrated Mice.Frontiers in cellular neuroscience · 2019Article
- Article
- Label-free imaging of neurotransmitters in live brain tissue by multi-photon ultraviolet microscopy.Neuronal signaling · 2018Review
- Sea urchin histamine receptor 1 regulates programmed cell death in larval Strongylocentrotus purpuratus.Scientific reports · 2018Article
- Extrasynaptic Neurotransmission Mediated by Exocytosis and Diffusive Release of Transmitter Substances.Frontiers in synaptic neuroscience · 2018Review
- On the Basis of Synaptic Integration Constancy during Growth of a Neuronal Circuit.Frontiers in cellular neuroscience · 2016Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Serotonin, a modulator of multiple functions in the nervous system, is released predominantly extrasynaptically from neuronal cell bodies, axons and dendrites. This paper describes how serotonin is released from cell bodies of Retzius neurons in the central nervous system (CNS) of the leech, and how it affects neighbouring glia and neurons. The large Retzius neurons contain serotonin packed in electrodense vesicles. Electrical stimulation with 10 impulses at 1 Hz fails to evoke exocytosis from the cell body, but the same number of impulses at 20 Hz promotes exocytosis via a multistep process. Calcium entry into the neuron triggers calcium-induced calcium release, which activates the transport of vesicle clusters to the plasma membrane. Exocytosis occurs there for several minutes. Serotonin that has been released activates autoreceptors that induce an inositol trisphosphate-dependent calcium increase, which produces further exocytosis. This positive feedback loop subsides when the last vesicles in the cluster fuse and calcium returns to basal levels. Serotonin released from the cell body is taken up by glia and released elsewhere in the CNS. Synchronous bursts of neuronal electrical activity appear minutes later and continue for hours. In this way, a brief train of impulses is translated into a long-term modulation in the nervous system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.