ReviewThe Journal of general physiology2015
The Hill analysis and co-ion-driven transporter kinetics.
Review in The Journal of general physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- The Charge of the Substrate Determines Sodium-Coupling Stoichiometry of the Amino Acid Transporter SLC6A14.Biochemistry · 2025Article
- Bacterial network for precise plant stress detection and enhanced crop resilience.BMC bioinformatics · 2025Article
- Initiation of epithelial wound closure by an active instability at the purse string.Biophysical journal · 2025Article
- Selective amino acid formulation enhances anion secretion and restores function in cystic fibrosis mutations.Frontiers in pharmacology · 2025Article
- Quantifying Plant Signaling Pathways by Integrating Luminescence-Based Biosensors and Mathematical Modeling.Biosensors · 2024Article
- Mathematical models describing oxygen binding by hemoglobin.Biophysical reviews · 2023Review
- High-speed atomic force microscopy reveals a three-state elevator mechanism in the citrate transporter CitS.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Solvent accessibility changes in a NaThe Journal of biological chemistry · 2020Article
- Copper-mediated thiol potentiation and mutagenesis-guided modeling suggest a highly conserved copper-binding motif in human OR2M3.Cellular and molecular life sciences : CMLS · 2020Article
- Cannabidiol Acts at 5-HTFrontiers in behavioral neuroscience · 2020Article
- Regulation of Amino Acid Transport in Saccharomyces cerevisiae.Microbiology and molecular biology reviews : MMBR · 2019Review
- Investigation of the allosteric coupling mechanism in a glutamate transporter homolog via unnatural amino acid mutagenesis.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Article
- Models to determine the kinetic mechanisms of ion-coupled transporters.The Journal of general physiology · 2019Article
- Article
- Coupled binding mechanism of three sodium ions and aspartate in the glutamate transporter homologue GltNature communications · 2016Article
- On the different sources of cooperativity in pH titrating sites of a membrane protein channel.The European physical journal. E, Soft matter · 2016Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Interaction of multiple ligands with a protein or protein complex is a widespread phenomenon that allows for cooperativity. Here, we review the use of the Hill equation, which is commonly used to analyze binding or kinetic data, to analyze the kinetics of ion-coupled transporters and show how the mechanism of transport affects the Hill coefficient. Importantly, the Hill analysis of ion-coupled transporters can provide the exact number of transported co-ions, regardless of the extent of the cooperativity in ion binding.
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