Rational strategy to stop arrhythmias: Early afterdepolarizations and L-type Ca2+ current.

Yogananda S Markandeya, Timothy J Kamp

Abstract readComment

In one paragraph

Article in The Journal of general physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it

0cells of the map it votes in

6citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

Therapeutic Approaches of Ryanodine Receptor-Associated Heart Diseases.International journal of molecular sciences · 2022
Review
Suppression of ventricular arrhythmias by targeting late L-type Ca2+ current.The Journal of general physiology · 2021
Article
L-type channel inactivation balances the increased peak calcium current due to absence of Rad in cardiomyocytes.The Journal of general physiology · 2021
Article
Circadian Rhythms of Early Afterdepolarizations and Ventricular Arrhythmias in a Cardiomyocyte Model.Biophysical journal · 2021
Article
Handling of Ventricular Fibrillation in the Emergency Setting.Frontiers in pharmacology · 2019
Review
Enhanced Late Na and Ca Currents as Effective Antiarrhythmic Drug Targets.Frontiers in pharmacology · 2017
Review

4 · The record

Corrections and comments

Comment on
Targeting the late component of the cardiac L-type Ca2+ current to suppress early afterdepolarizations.2015

5 · Who and what money

Authors and funding

2 authors.

Yogananda S MarkandeyaDepartment of Medicine and Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI 53705 Department of Medicine and Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI 53705.

Timothy J KampDepartment of Medicine and Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI 53705 Department of Medicine and Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI 53705 tjk@medicine.wisc.edu.

Funding

Caveolae and L-type Calcium Channels in CardiomyocytesR01HL078878 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI BALIJEPALLI, RAVI CHANDRA, KAMP, TIMOTHY J. · 2007 to 2016

$3.1M

NHLBI NIH HHS R01 HL078878

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Action PotentialsAnimalsCalcium Channels, L-TypeMaleMyocytes, CardiacCalcium Channels, L-Type

Identifiers

PMID26009542

DOI10.1085/jgp.201511429

PMCPMC4442792

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-SA

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.