Evidence map›Paper›PMID 26009492›Full record

ArticleClinical biomechanics (Bristol, Avon)2015

Biomechanical evaluation of a novel suturing scheme for grafting load-bearing collagen scaffolds for rotator cuff repair.

Anowarul Islam, Michael S Bohl, Andrew G Tsai, Mousa Younesi, Robert Gillespie, Ozan Akkus

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical biomechanics (Bristol, Avon), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Regenerative Engineering of the Rotator Cuff of the Shoulder.ACS biomaterials science & engineering · 2018
    Article
  10. Article
  11. Article
  12. Current Status of Tissue-Engineered Scaffolds for Rotator Cuff Repair.Techniques in orthopaedics (Rockville, Md.) · 2016
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Anowarul IslamDepartment of Mechanical and Aerospace Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.
Michael S BohlThe Warren Alpert Medical School of Brown University, Providence, RI 02912, USA.
Andrew G TsaiDepartment of Orthopaedics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Mousa YounesiDepartment of Mechanical and Aerospace Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.
Robert GillespieDepartment of Orthopaedics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Ozan AkkusDepartment of Mechanical and Aerospace Engineering, Case Western Reserve University, Cleveland, OH 44106, USA; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA; Department of Orthopaedics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. Electronic address: oxa@case.edu.
Case Western Reserve University · USBrown University · US

Funding

Tendon Tissue Engineering by Electrochemically Aligned Collagen BioscaffoldsR01AR063701 · NIAMS · CASE WESTERN RESERVE UNIVERSITY · PI AKKUS, OZAN · 2014 to 2018
$1.9M
NIAMS NIH HHS R01 AR063701
6 · The paper itself

Abstract

backgroundCurrently, there are no well-established suture protocols to attach fully load-bearing scaffolds which span tendon defects between bone and muscle for repair of critical sized tendon tears. Methods to attach load-bearing tissue repair scaffolds could enable functional repair of tendon injuries.

methodsSixteen rabbit shoulders were dissected (New Zealand white rabbits, 1yr. old, female) to isolate the humeral-infraspinatus muscle complex. A unique suture technique was developed to allow for a 5mm segmental defect in infraspinatus tendon to be replaced with a mechanically strong bioscaffold woven from pure collagen threads. The suturing pattern resulted in a fully load-bearing scaffold. The tensile stiffness and strength of scaffold repair were compared with intact infraspinatus and regular direct repair.

findingsThe failure load and displacement at failure of the scaffold repair group were 59.9N (standard deviation, SD=10.7) and 10.3mm (SD=2.9), respectively and matched those obtained by direct repair group which were 57.5N (SD=15.3) and 8.6mm (SD=1.5), (p>0.05). Failure load, displacement at failure and stiffness of both of the repair groups were half of the intact infraspinatus shoulder group.

interpretationWith the developed suture technique, scaffold repair showed similar failure load, displacement at failure and stiffness to the direct repair. This novel suturing pattern and the mechanical robustness of the scaffold at time zero indicates that the proposed model is mechanically viable for future in vivo studies which has a higher potential to translate into clinical uses.

Indexed as

Suture TechniquesTissue ScaffoldsAnimalsBiomechanical PhenomenaCollagenDisease Models, AnimalFemaleRabbitsRotator CuffRotator Cuff InjuriesTendon InjuriesWeight-BearingWound HealingCollagenCollagen suture techniqueInfraspinatus tendonMechanical propertiesScaffoldSegmental rotator cuff defectStrength

Identifiers

PMID26009492
PMCPMC4523401
OpenAlexW1550748500

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.