ReviewCurrent neurology and neuroscience reports2015
The relationship between atrophy and hypometabolism: is it regionally dependent in dementias?
Review in Current neurology and neuroscience reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- SynthPET: A 3D generative AI approach for FDG-PET image synthesis from T1-weighted MRI and ASL CBF in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Anterior temporal lobe, word comprehension, and physiology of atrophy in semantic primary progressive aphasia.Neurocase · 2025Article
- Personalized neurometabolic signature predicts seizure outcomes of laser ablation in mesial temporal lobe epilepsy.Communications medicine · 2025Article
- Central Obesity Disrupts Brain Network Organization in Aging via Metabolic and Structural Pathways.Aging and disease · 2025Article
- Cortical hypometabolism in Parkinson's disease is linked to cholinergic basal forebrain atrophy.Molecular psychiatry · 2025Article
- Imaging biomarkers of cortical neurodegeneration underlying cognitive impairment in Parkinson's disease.European journal of nuclear medicine and molecular imaging · 2025Article
- Distinct cerebral cortical perfusion patterns in idiopathic normal-pressure hydrocephalus.Human brain mapping · 2023Article
- Functional connectivity to the premotor cortex maps onto longitudinal brain neurodegeneration in progressive apraxia of speech.Neurobiology of aging · 2022Article
- Assessment of the In Vivo Relationship Between Cerebral Hypometabolism, Tau Deposition, TSPO Expression, and Synaptic Density in a Tauopathy Mouse Model: a Multi-tracer PET Study.Molecular neurobiology · 2022Article
- Mild Behavioral Impairment Is Associated With Atrophy of Entorhinal Cortex and Hippocampus in a Memory Clinic Cohort.Frontiers in aging neuroscience · 2021Article
- Diagnostic performance of an automated analysis software for the diagnosis of Alzheimer's dementia withAmerican journal of nuclear medicine and molecular imaging · 2017Article
- Relationship between neuroimaging and cognition in frontotemporal dementia: An FDG-PET and structural MRI study.Journal of neuroimaging : official journal of the American Society of NeuroimagingArticle
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuronal failure leading to dementia in neurodegenerative diseases is evidenced in vivo by functional and structural changes in the brain such as reductions of glucose consumption and volume of grey matter. The earliest phase of cognitive decline and presymptomatic stages of these diseases are heralded by specific patterns of hypometabolism, even in the absence of atrophy, which are currently considered as diagnostic biomarkers. Atrophy is less consistently found as an initial marker of these diseases and is invariably present in moderate to severe stages with a disease-related topography. The relationship between these two markers is not uniform, but in the two diseases in which they have been directly compared, Alzheimer's and Parkinson's disease, altered hypometabolism precedes and exceeds atrophy in most regions. This suggests a two-step degenerative process. In contrast to these findings, the hippocampus skips this pattern and is more structurally than functionally affected, thereby suggesting a different pathological mechanism in this particular area. More studies are needed to disentangle the mechanisms underlying both markers and their relationship in neurodegenerative diseases.
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Registered trials
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